Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MONAJJEMZADEH FARNAZ; BAGHERI MAHSA; MONTAZAM SEYED HASSAN; JELVEHGARI MITRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2018 | Volume:24 | Issue:1 Page(s): 60-70

Download Full-Text

View:

117

Download:

Cites:

Information Journal Paper

Title

Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability

Author(s)

MONAJJEMZADEH FARNAZ | BAGHERI MAHSA | MONTAZAM SEYED HASSAN | JELVEHGARI MITRA | Issue Writer Certificate

Keywords

Muco‐adhesive

Microsphere

Hydroxypropyl methylcellulose

Selegiline

Disc

Abstract

Background: Selegiline hydrochloride (Sel) is a drug applied for the therapy of early‐ step Parkinson's disease. In usual clinical doses, it is an elective irreversible MAO-B inhibitor. This study intended to formulate mucoadhesive Microspheres of Selegiline with the objective of improving the therapeutic efficacy, patient compliance and bioavailability. Methods: The Microspheres were prepared by emulsion solvent evaporation method (O1/ O2) using Hydroxypropyl methylcellulose (HPMC). In the current study, bucco‐ adhesive Microspheres were prepared with different drug to polymer ratios and characterized by encapsulation efficiency, particle size, Differential Scanning Calorimetry (DSC), FTIR Fourier Transform Infrared Spectroscopy (FTIR), flowability, the degree of swelling and surface pH, mucoadhesive character, retentive time, and drug release studies. Results: The best drug to polymer ratio in Microspheres was 1: 2 (as F1). The production yield Microspheres F1 showed production yield of 84. 79%, mean particle size of 744. 73 μ m and loading efficiency of 53. 33%. The DSC exhibited the property of Selegiline loaded Microspheres changed to amorphous form. The FTIR spectrum proposed that the drug kept its chemical stability during the emulsification process. The results showed that the Microspheres of F1 had faster release than the Microspheres of F2 (1: 4), F3 (1: 6), and commercial tablet (p<0. 05). The Microspheres did not exhibit good retention time properties (276. 66‐ 329. 66 min). The results of mucoadhesion strength (8. 3‐ 18. 3 g/cm2) and surface pH of Discs (6. 44‐ 6. 97) showed the better characterization of Microspheres in buccal. Conclusion: The formulations were found to be appropriate candidates for the improvement of Microspheres for the remedial objects.

Cites

No record.

References

No record.

Cite

APA: Copy

MONAJJEMZADEH, FARNAZ, BAGHERI, MAHSA, MONTAZAM, SEYED HASSAN, & JELVEHGARI, MITRA. (2018). Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability. PHARMACEUTICAL SCIENCES, 24(1), 60-70. SID. https://sid.ir/paper/734963/en

Vancouver: Copy

MONAJJEMZADEH FARNAZ, BAGHERI MAHSA, MONTAZAM SEYED HASSAN, JELVEHGARI MITRA. Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability. PHARMACEUTICAL SCIENCES[Internet]. 2018;24(1):60-70. Available from: https://sid.ir/paper/734963/en

IEEE: Copy

FARNAZ MONAJJEMZADEH, MAHSA BAGHERI, SEYED HASSAN MONTAZAM, and MITRA JELVEHGARI, “Preparation and In Vitro/Ex Vivo Evaluation of Buccoadhesive Discs of an Anti-Parkinson Drug: Relationship between Mucoadhesivity, Drug Release and Permeability,” PHARMACEUTICAL SCIENCES, vol. 24, no. 1, pp. 60–70, 2018, [Online]. Available: https://sid.ir/paper/734963/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops