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Information Journal Paper

Title

GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/ Akt pathway

Pages

  729-735

Abstract

 Objective(s): The current study was aimed to investigate the effect of morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) on ipsilateral Epididymis injury in a rat model of experimental Varicocele (VC). Materials and Methods: Sixty Wistar rats were randomly assigned to sham, sham plus GYY4137, VC and VC plus GYY4137 groups. Sperm quality parameters, including sperm count, motility and viability were evaluated after 4 weeks. Histological changes were measured by hematoxylin and eosin staining between the groups. The oxidative stress levels were estimated by determining epididymal superoxide dismutase (SOD) and malondialdehyde (MDA). The Apoptosis status and the expression of phosphatidylinositol 3′-OH kinase (PI3K)/Akt were analyzed by immunohistochemical analysis, western blot and RT-qPCR. Results: VC resulted in the decrease of sperm parameters, significant histological damage and higher levels of oxidative stress and Apoptosis. Compared to the VC group, GYY4137 markedly ameliorated these observed changes. In addition, treatment with GYY4137 obviously reduced the levels of caspase-3 and Bax and increased the levels of the phosphorylation of PI3K p85 and Akt. Conclusion: Our data demonstrated that GYY4137 may alleviate the sperm damage and Epididymis injury in experimentally VC-induced rats by activation of the PI3K/Akt pathway.

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    APA: Copy

    Xia, Yu qi, Ning, Jin zhuo, Cheng, Fan, Yu, Wei min, Rao, Ting, Ruan, Yuan, Yuan, Run, & Du, Yang. (2019). GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/ Akt pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(7), 729-735. SID. https://sid.ir/paper/735148/en

    Vancouver: Copy

    Xia Yu qi, Ning Jin zhuo, Cheng Fan, Yu Wei min, Rao Ting, Ruan Yuan, Yuan Run, Du Yang. GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/ Akt pathway. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(7):729-735. Available from: https://sid.ir/paper/735148/en

    IEEE: Copy

    Yu qi Xia, Jin zhuo Ning, Fan Cheng, Wei min Yu, Ting Rao, Yuan Ruan, Run Yuan, and Yang Du, “GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K/ Akt pathway,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 7, pp. 729–735, 2019, [Online]. Available: https://sid.ir/paper/735148/en

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