مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

209
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

132
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The impact of Lactobacillus acidophilus on hepatic and colonic fibrosis induced by ethephon in a rat model

Pages

  956-962

Abstract

 Objective(s): The study is aimed to elucidate the impact of antioxidant, anti-inflammatory and antifibrosis properties of Lactobacillus acidophilus (L. acidophilus) on liver and colon in Ethephon treated rats through measuring Pro-inflammatory cytokines, oxidative stress index, lysosomal cathepsin-D enzyme activity and fibrosis markers. Materials and Methods: Rats divided into three groups; Group 1: distilled water control, Group 2: rats at day 16 from experiment beginning were orally received Ethephon 50 mg/ kg BW in distilled water once daily for 60 days. Group 3: rats were orally received L. acidophilus enriched diet 1% (w/w) for 15 days as prophylactic, then received both L. acidophilus enriched diet 1% (w/w) and Ethephon 50 mg/kg BW for 60 days. Results: Ethephon exerts hepatic and colonic oxidative stress, inflammatory response and fibrosis through NF-κ B activation. On contrary, L. acidophilus supplementation evokes hepatoprotective properties as revealed by decreased serum AST, ALT, γ-GT and increased IGF-1. L. acidophilus exerts antioxidant and anti-inflammatory properties as indicated by decreased TOS, OSI, TNF-α , IL-1β , cathepsins D activity, NF-κ B expression and increased TAC, lysosomal membrane stability. L. acidophilus shows antifibrotic activity as demonstrated by down-regulation of TGF-β 1, α-SMA, collagen expression. Conclusion: L. acidophilus possess antioxidant, anti-inflammatory and antifibrotic activity through inhibition of NF-kB.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Bahr, Hoda I., Hamad, Rania, & A. Ismail, Shimaa A.. (2019). The impact of Lactobacillus acidophilus on hepatic and colonic fibrosis induced by ethephon in a rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(8), 956-962. SID. https://sid.ir/paper/735165/en

    Vancouver: Copy

    Bahr Hoda I., Hamad Rania, A. Ismail Shimaa A.. The impact of Lactobacillus acidophilus on hepatic and colonic fibrosis induced by ethephon in a rat model. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(8):956-962. Available from: https://sid.ir/paper/735165/en

    IEEE: Copy

    Hoda I. Bahr, Rania Hamad, and Shimaa A. A. Ismail, “The impact of Lactobacillus acidophilus on hepatic and colonic fibrosis induced by ethephon in a rat model,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 8, pp. 956–962, 2019, [Online]. Available: https://sid.ir/paper/735165/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button