THE EFFECT OF HYDROALCOHOLIC EXTRACT OF MELISSA OFFICINALIS IN PREVENTION OF CONVULSIONS INDUCED BY NICOTINE IN MICE

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ARZI A.; SHAFIEE M.

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Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2002 | Volume:4 | Issue:2 (14) Page(s): 18-22

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF MELISSA OFFICINALIS IN PREVENTION OF CONVULSIONS INDUCED BY NICOTINE IN MICE

Author(s)

ARZI A. | SHAFIEE M. | Issue Writer Certificate

Keywords

MELISSA OFFICINALISQ3

CONVULSIONSQ3

NICOTINEQ3

Abstract

BACKGROUND AND OBJECTIVE: Hydroalcoholic extract of melissa officinal is (MO) has been considered as an anticonvulsant in traditional medicine. This study was done to determine its effect in prevention of CONVULSIONS induced by NICOTINE in mice. METHODS: Normal saline (10ml/kg) was injected to control group (i.p). After preparation of hydroalcoholic extract of MO by maceration method, doses of 200, 400, 600, 800 and 1000 mg/kg of this extract were administered separately at 0, 15, 30 and 45 minutes before injection of NICOTINE. Then intensity, duration and latency of CONVULSIONS and mortality rate were surveyed.FINDINGS: Administration of the extract with doses of 800 and 1000 mg/kg at 15, 30 and 45 minutes and with dose of 600 mg/kg at 30 min before injection of NICOTINE significantly increased the latency of CONVULSIONS (p <0.05). None of administered doses changed the intensity of CONVULSIONS significantly.CONCLUSION: Obtained results showed that hydroalcoholic extract of MELISSA OFFICINALIS (MO) cause to increase latency and intensity of CONVULSIONS induced by NICOTINE.

Cites

اثر عصاره هیدرو الکلی آویشن در پیشگیری از تشنج ناشی از نیکوتین

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APA: Copy

ARZI, A., & SHAFIEE, M.. (2002). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF MELISSA OFFICINALIS IN PREVENTION OF CONVULSIONS INDUCED BY NICOTINE IN MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 4(2 (14)), 18-22. SID. https://sid.ir/paper/73546/en

Vancouver: Copy

ARZI A., SHAFIEE M.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF MELISSA OFFICINALIS IN PREVENTION OF CONVULSIONS INDUCED BY NICOTINE IN MICE. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2002;4(2 (14)):18-22. Available from: https://sid.ir/paper/73546/en

IEEE: Copy

A. ARZI, and M. SHAFIEE, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF MELISSA OFFICINALIS IN PREVENTION OF CONVULSIONS INDUCED BY NICOTINE IN MICE,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 4, no. 2 (14), pp. 18–22, 2002, [Online]. Available: https://sid.ir/paper/73546/en

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