ASSESSMENT OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF INULA HELENIUMD.C IN ADULT MALE RAT

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FALLAHZADEH A.R.; MOHAMMADI S.

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Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2016 | Volume:18 | Issue:12 Page(s): 57-63

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Title

ASSESSMENT OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF INULA HELENIUMD.C IN ADULT MALE RAT

Author(s)

FALLAHZADEH A.R. | MOHAMMADI S. | Issue Writer Certificate

Keywords

INFLAMMATIONQ2

PAINQ2

INULA HELENIUMQ1

MEDICINAL PLANTQ2

Abstract

BACKGROUND AND OBJECTIVE: INULA HELENIUM is a MEDICINAL PLANT with proven anti-cancer, anti-microbial and anti-fungal effects. The aim of this study is to investigate the antinociceptive and anti-inflammatory effects of hydroalcoholic extract of INULA HELENIUM leaf on male rats.METHODS: 66 male rats were used in this experimental study. The animals were divided into 6 groups (each group consisted of 6 rats) for PAIN assessment tests: control group, groups treated with the extract (50, 100 and 300 mg/kg), morphine and naloxone in combination with 300 mg/kg extract. Furthermore, they were divided into 5 groups (each group consisted of 6 rats) for anti-inflammatory tests: control group, groups treated with the extract (10, 50 and 100 mg/kg) and dexamethasone. Tail-flick, rating and formalin tests were used to assess PAIN and xylene test was used to assess INFLAMMATION.FINDINGS: According to the results of rating (28.21±1.34) and tail-flick (5.11±1.34) tests, using 300 mg/kg extract had significant antinociceptive effect (p<0.01) compared with control group (41.22±4.12). According to the formalin test, using 100 mg/kg extract decreased PAIN rating from 2.17±0.21 in control group to 0.53±0.24, in the chronic phase (p<0.05). According to the xylene test, using 50 and 100 mg/kg extract decreased the INFLAMMATION of the ear in rats (4.1±2 and 3.3±1, respectively) compared with control group (0.4±7.6) (p<0.001 and p<0.01).CONCLUSION: Results of this study showed that hydroalcoholic extract of INULA HELENIUM leaf may benefit from antinociceptive and anti-inflammatory effects

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APA: Copy

FALLAHZADEH, A.R., & MOHAMMADI, S.. (2016). ASSESSMENT OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF INULA HELENIUMD.C IN ADULT MALE RAT. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 18(12), 57-63. SID. https://sid.ir/paper/73621/en

Vancouver: Copy

FALLAHZADEH A.R., MOHAMMADI S.. ASSESSMENT OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF INULA HELENIUMD.C IN ADULT MALE RAT. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2016;18(12):57-63. Available from: https://sid.ir/paper/73621/en

IEEE: Copy

A.R. FALLAHZADEH, and S. MOHAMMADI, “ASSESSMENT OF THE ANTINOCICEPTIVE AND ANTIINFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF INULA HELENIUMD.C IN ADULT MALE RAT,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 18, no. 12, pp. 57–63, 2016, [Online]. Available: https://sid.ir/paper/73621/en

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