Synergistic or Antagonistic Effects of Probiotics and Antibiotics-Alone or in Combination-on Antimicrobial-Resistant Pseudomonas aeruginosa Isolated from BurnWounds

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Soleymanzadeh Moghadam Somayeh; KHODAII ZOHREH; FATHIZADEH SARA; Ghooshchian Maryam; Fagheei Aghmiyuni Zeinab; Mousavi Shabestari Tahereh

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Journal: Archives of Clinical Infectious Diseases Year:2018 | Volume:13 | Issue:3 Page(s): 0-0

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Title

Synergistic or Antagonistic Effects of Probiotics and Antibiotics-Alone or in Combination-on Antimicrobial-Resistant Pseudomonas aeruginosa Isolated from BurnWounds

Author(s)

Keywords

Burn

Antibiotic

Probiotic

Lactobacillus planetarum

Abstract

Background: Bacterial Burn infections are one of the serious infections and since their treatment with Antibiotics is very difficult, infection control in such wounds is very important. Therefore, methods should be sought to enhance the effects of Antibiotics and also reduce the resistance to them. It seems that Probiotics have antimicrobial features and are effective in wound healing. Objectives: The current study aimed at evaluating and comparing the antimicrobial effects of Antibiotics and Probiotics, as well as their combination on bacterial Burn infections. Methods: Thirty clinically resistant Pseudomonas aeruginosa species isolated from hospitalized patients with Burn wounds were collected. Antibacterial activity of five Antibiotics and 11 Probiotic strains, and also their combination were evaluated by disk diffusion method. One-way ANOVA and Tukey post hoc test were used for data analysis. Results: It was found that the effect of inhibitory zone in combination use of tetracycline + a Probiotic strain was more than using the Antibiotic and Probiotic alone. Also, the current study found that among the Probiotics, Lactobacillus plantarum 299v had the highest effect, although not significant, on resistant P. aeruginosa. The current study explained that the inhibitory effect of L. plantarum 299v was significantly higher than that of ciprofloxacin (P = 0. 009). In addition, antibacterial activity of gentamicin + L. salivarius (ES1) was significantly higher compared with that of gentamicin + L. routeri (P = 0. 01). Conclusions: The current study explained that Probiotics had a useful potential inhibitory effect on the growth of the pathogens. The study showed that in most cases, inhibitory zones of Probiotics were greater than those of Antibiotics as well as combination of Antibiotic + Probiotic. But, there was an exception in tetracycline, which had synergistic effect with Probiotics. Conversely, in the cases of imipenem and chloramphenicol, addition of Probiotics had antagonistic effects. Further studies are needed to describe different results. Therefore, itseemsthat the type of AntibioticsandProbiotics are important to create the synergistic or antagonistic effects.

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APA: Copy

Soleymanzadeh Moghadam, Somayeh, KHODAII, ZOHREH, FATHIZADEH, SARA, Ghooshchian, Maryam, Fagheei Aghmiyuni, Zeinab, & Mousavi Shabestari, Tahereh. (2018). Synergistic or Antagonistic Effects of Probiotics and Antibiotics-Alone or in Combination-on Antimicrobial-Resistant Pseudomonas aeruginosa Isolated from BurnWounds. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 13(3), 0-0. SID. https://sid.ir/paper/738899/en

Vancouver: Copy

Soleymanzadeh Moghadam Somayeh, KHODAII ZOHREH, FATHIZADEH SARA, Ghooshchian Maryam, Fagheei Aghmiyuni Zeinab, Mousavi Shabestari Tahereh. Synergistic or Antagonistic Effects of Probiotics and Antibiotics-Alone or in Combination-on Antimicrobial-Resistant Pseudomonas aeruginosa Isolated from BurnWounds. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2018;13(3):0-0. Available from: https://sid.ir/paper/738899/en

IEEE: Copy

Somayeh Soleymanzadeh Moghadam, ZOHREH KHODAII, SARA FATHIZADEH, Maryam Ghooshchian, Zeinab Fagheei Aghmiyuni, and Tahereh Mousavi Shabestari, “Synergistic or Antagonistic Effects of Probiotics and Antibiotics-Alone or in Combination-on Antimicrobial-Resistant Pseudomonas aeruginosa Isolated from BurnWounds,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 13, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/738899/en

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