Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis

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Rezapour Firouzi Soheila; KHERADMAND FATEMEH; Shahabi Sharam; TEHRANI ALI ASGHAR; Mazloomi Ebrahim; MOHAMMADZADEH ADEL

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Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2019 | Volume:14 | Issue:2 Page(s): 146-154

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Title

Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis

Author(s)

Keywords

Autoimmune

Encephalomyelitis

Lymphocytes

Rapamycin

T cell

Abstract

T helper (Th)-17 mediate inflammation in both peripheral tissues and the central nervous system. Signal transducer and activator of transcription factor3 (STAT3) is required for Th-cell pathogenicity and its activation in the brain has been demonstrated during the acute phase of experimental Autoimmune Encephalomyelitis (EAE) through the mammalian target of Rapamycin (mTOR) signaling. Rapamycin (RAPA), an inhibitor of mTOR, can drive Forkhead box P3 (FOXP3+) induction as a regulatory factor. The aim of this study was to determine the effects of hemp seed/evening primrose oils (HSO/EPO) supplement on the expression of FOXP3+, STAT3, and interleukin (IL)-17 genes in EAE lymph nodes. EAE was induced by myelin oligodendrocyte glycoprotein peptide in mice, and then the mice were assigned to three treatment groups compared to two control groups (EAE and naive). The histological findings of the spinal cord were evaluated. To determine the expression of FOXP3+, STAT3, and IL-17 genes in the Lymphocytes, qRT-PCR was used. Our results showed that EAE severity was reduced in HSO/EPO mice by reducing the expression of STAT3 and IL-17 genes and increasing the expression of FOXP3+ gene, which was confirmed by slight inflammation in the spinal cord. Histological findings showed a significant improvement in the HSO/EPO group. Our findings suggest that the HSO/EPO treatment can be used to ameliorate the demyelination of spinal cord, which was confirmed by immunological and histological findings.

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APA: Copy

Rezapour Firouzi, Soheila, KHERADMAND, FATEMEH, Shahabi, Sharam, TEHRANI, ALI ASGHAR, Mazloomi, Ebrahim, & MOHAMMADZADEH, ADEL. (2019). Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 14(2), 146-154. SID. https://sid.ir/paper/739044/en

Vancouver: Copy

Rezapour Firouzi Soheila, KHERADMAND FATEMEH, Shahabi Sharam, TEHRANI ALI ASGHAR, Mazloomi Ebrahim, MOHAMMADZADEH ADEL. Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2019;14(2):146-154. Available from: https://sid.ir/paper/739044/en

IEEE: Copy

Soheila Rezapour Firouzi, FATEMEH KHERADMAND, Sharam Shahabi, ALI ASGHAR TEHRANI, Ebrahim Mazloomi, and ADEL MOHAMMADZADEH, “Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 14, no. 2, pp. 146–154, 2019, [Online]. Available: https://sid.ir/paper/739044/en

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