Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran

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NAVIDINIA MASOUMEH; GOUDARZI HOSSEIN; Pouriran Ramin; AZIMI HADI; GOUDARZI MEHDI

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Journal: Archives of Clinical Infectious Diseases Year:2019 | Volume:14 | Issue:1 Page(s): 0-0

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Title

Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran

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Keywords

Mupirocin

Polymerase Chain Reaction

Methicillin-Resistant S.aureus

Spa typing

Abstract

Background: The prevalence of wound infections associated with multidrug-resistant Staphylococcus aureus (S. aureus) strains among burns patients has tremendously increased. Recently, the role of integrons as a key system involved in spreading multi-drug resistance has been well documented. Objectives: To investigate the prevalence of integrons, antimicrobial resistance pattern, and S. aureus protein A (spa) typing of the Mupirocin-resistant S. aureus (MRSA) strains obtained from a referral burns hospital in Tehran, Iran. Methods: This study was performed during January 2017 to April 2018 on 64 MRSA isolates gathered from burns patients. The isolates were examined for susceptibility to antimicrobial agents. The integrase-encoding gene was detected by conventional Polymerase Chain Reaction (PCR). Integrase-positive strains were evaluated for the determination of integron classes by using PCR-restriction fragment length polymorphism assay, and genotyping was performed by Spa typing. Results: Out of 64 MRSA strains, 24 (37. 5%) and 40 (62. 5%) isolates carried high-level and low-level resistance, respectively. The ﬁ ndings revealed that the entire isolates were MRSA. They belonged to six diﬀ erent spa types including t860 (40. 6%), t790 (21. 8%), t037 (17. 2%), t064 (17. 2%), t008 (1. 6%), and t631 (1. 6%). Class 1 and 2 integrons were found in 59. 4% and 17. 2% of the isolates, respectively, and 4 (6. 2%) isolates were observed to carry class 1 and 2 integrons simultaneously. Conclusions: Precise epidemiological monitoring of integrons is required to prevent Mupirocin resistance dissemination in MRSA strains.

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APA: Copy

NAVIDINIA, MASOUMEH, GOUDARZI, HOSSEIN, Pouriran, Ramin, AZIMI, HADI, & GOUDARZI, MEHDI. (2019). Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 14(1), 0-0. SID. https://sid.ir/paper/739070/en

Vancouver: Copy

NAVIDINIA MASOUMEH, GOUDARZI HOSSEIN, Pouriran Ramin, AZIMI HADI, GOUDARZI MEHDI. Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2019;14(1):0-0. Available from: https://sid.ir/paper/739070/en

IEEE: Copy

MASOUMEH NAVIDINIA, HOSSEIN GOUDARZI, Ramin Pouriran, HADI AZIMI, and MEHDI GOUDARZI, “Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 14, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/739070/en

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