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Information Journal Paper

Title

Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii

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Abstract

 Background: Adhesion to host cells is an important and critical feature of Acinetobacter baumannii pathogenesis. OmpA, ABAYE1319-CsuA/b, and ABAYE2132 are highly prevalent and conserved fimbrial proteins; ABAYE1859 and ABAYE0304 fimbrial antigens are the factors described as novel vaccine candidates against multidrug-resistant (MDR) A. baumannii. Methods: The current study aimed at investigating the significance of A. baumannii fimbrialandoutermembraneproteinsA(OmpA) in adherence to human epithelial cells. Antibiotic Resistance was determined by the broth microdilution method. Phenotypic identification of isolates producing ESBL (extended-spectrum beta-lactamase) was conducted using double-disc synergy test (DDST). The Virulence Factors were detected by the polymerase chain reaction (PCR) in 100 non duplicate clinical isolates of A. baumannii; 18 clinical isolates were selected for adhesion assay based on Antibiotic Resistance and PCR results. Results: The current study results showed that ABAYE2132, ABAYE0304, and ABAYE1319-CsuA/B had significant correlation with Cell Adhesion (P 0. 05). There was no significant correlation between Cell Adhesion and ABAYE1859 (P 0. 05). ABAYE2132 was the most effective factor in Cell Adhesion. It was also observed that Cell Adhesion rate reduced with the increase of fimbrial proteins. Conclusions: The current study findings suggested that different products and structures of A. baumannii, most still unknown, play a pivotal role in pathogen-biotic reactions. Better exposure of some non-pili adhesins or other biofilm forming factors could be a reason for this phenomenon.

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    APA: Copy

    Afshar Payam, Maryam, RASOOLI, IRAJ, OWLIA, PARVIZ, TALEI, DARYUSH, DARVISH ALIPOUR ASTANEH, SHAKIBA, & NAZARIAN, SHAHRAM. (2018). Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 13(3), 0-0. SID. https://sid.ir/paper/740067/en

    Vancouver: Copy

    Afshar Payam Maryam, RASOOLI IRAJ, OWLIA PARVIZ, TALEI DARYUSH, DARVISH ALIPOUR ASTANEH SHAKIBA, NAZARIAN SHAHRAM. Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2018;13(3):0-0. Available from: https://sid.ir/paper/740067/en

    IEEE: Copy

    Maryam Afshar Payam, IRAJ RASOOLI, PARVIZ OWLIA, DARYUSH TALEI, SHAKIBA DARVISH ALIPOUR ASTANEH, and SHAHRAM NAZARIAN, “Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 13, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/740067/en

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