Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study

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ALISHIRI GHOLAMHOSSEIN; HESHMAT GHAHDARIJANI KIYAN; HASHEMI MOHAMMAD; Zavar Reihaneh; MOSHKANI FARAHANI MARYAM

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2020 | Volume:25 | Issue:6 Page(s): 0-0

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Title

Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study

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Keywords

Alendronate

aortic stenosis

N‑terminal‑prohormone of brain natriuretic peptide

osteoporosis

Abstract

Background: aortic stenosis (AS) is the most common primary valvular disease. Currently, there is no pharmacological approach for the medical management of AS. We investigated the effect of osteoporosis therapy with Alendronate on hemodynamic progression in patients concurrently affected by AS and osteoporosis. Materials and Methods: In this observational prospective study, we enrolled 37 women more than 60 years old with diagnosis of AS and concurrent osteoporosis from August 2017 to December 2019. These patients were treated with Alendronate 70 mg every week added to their routine treatment for AS, and their outcomes were compared with 33 patients only affected by AS. Echocardiographic changes and N‑ terminal‑ prohormone of brain natriuretic peptide (NT‑ pro‑ BNP) level were evaluated during about 2 years of follow‑ up. Results: The mean follow‑ up time for the treated and nontreated groups was 20. 89 ± 2. 73 and 20. 84 ± 2. 76 months, respectively. Mean gradient (P = 0. 02) and peak gradient (P = 0. 04) of aortic valve were significantly different between the groups after follow‑ up. Aortic valve area was decreased 0. 09 cm2 in the treated group by Alendronate and 0. 23 cm2 in the other group (P = 0. 001). Furthermore, NT‑ pro‑ BNP was significantly decreased in patients treated by Alendronate (P = 0. 01), but it was increased in nontreated patients (P = 0. 04). Conclusion: Treatment with Alendronate in patients with AS and concurrent osteoporosis slows down the progression of stenosis and improves their prognosis. This study could open a new pathway for the treatment of AS. Further studies, particularly randomized controlled clinical trial, should be done for providing more evidence.

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APA: Copy

ALISHIRI, GHOLAMHOSSEIN, HESHMAT GHAHDARIJANI, KIYAN, HASHEMI, MOHAMMAD, Zavar, Reihaneh, & MOSHKANI FARAHANI, MARYAM. (2020). Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 25(6), 0-0. SID. https://sid.ir/paper/740161/en

Vancouver: Copy

ALISHIRI GHOLAMHOSSEIN, HESHMAT GHAHDARIJANI KIYAN, HASHEMI MOHAMMAD, Zavar Reihaneh, MOSHKANI FARAHANI MARYAM. Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2020;25(6):0-0. Available from: https://sid.ir/paper/740161/en

IEEE: Copy

GHOLAMHOSSEIN ALISHIRI, KIYAN HESHMAT GHAHDARIJANI, MOHAMMAD HASHEMI, Reihaneh Zavar, and MARYAM MOSHKANI FARAHANI, “Alendronate slows down aortic stenosis progression in osteoporotic patients: An observational prospective study,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 25, no. 6, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/740161/en

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