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Information Journal Paper

Title

Characterization and Stability of the Antimony-Quercetin Complex

Pages

  432-438

Abstract

 Purpose: Quercetin is a flavonoid known for its therapeutic properties and for forming complexes. Although the Antimony-Quercetin (SbQ) complex has been produced before, no previous exploration of its characteristics has been published in literature. Thus, this study aimed to characterize this complex, assess its stability and investigate its complexation site through its antibacterial activity. Methods: The SbQ complex was synthetized using Sb(III) potassium tartrate trihydrate and Quercetin anhydrous (1: 1) (v/v) as a solution and dried using three methods: rotaevaporation, lyophilization and spray drying. The material, in solution, was analyzed by UV-vis and fluorimetry; and, in the powder, by X-ray diffraction (XRD), both scanning electronic and fluorescence microscopy and infrared spectroscopy (FT-IR). Antimicrobial activity was evaluated via broth microdilution. Results: UV-vis exhibited a shoulder peak at 291 nm indicating metal chelation at C-ring of Quercetin and confirmed 1: 1 stoichiometry. Spectrofluorimetry showed an increase of intensity with the complex formation with an emission band (525 nm). After drying, XRD and SEM indicated loss of crystallinity and a difference in shape and size of the complex compared to its precursors. FT-IR suggested by a shift of frequency of the carbonyl group (1661 cm-1) that the Quercetin bond to Antimony by the C-3, followed by positions C-5 and C-4 carbonyl, which has been confirmed by MIC through the structure-activity relationship of the antibacterial activity of Quercetin. Conclusion: These results provided a characterization of SbQ complex with the confirmation of its binding site, working as a guide for future studies involving this complex.

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    APA: Copy

    Barbosa, Valcilaine Teixeira, de Menezes, Janaina Barros, Caldas Santos, Josue Carinhanha, de Assis Bastos, Maria Lysete, de Araujo Junior, Joao Xavier, do Nascimento, Ticiano Gomes, Basilio Junior, Irinaldo Diniz, Meireles Grillo, Luciano Aparecido, & Dornelas, Camila Braga. (2019). Characterization and Stability of the Antimony-Quercetin Complex. ADVANCED PHARMACEUTICAL BULLETIN, 9(3), 432-438. SID. https://sid.ir/paper/740182/en

    Vancouver: Copy

    Barbosa Valcilaine Teixeira, de Menezes Janaina Barros, Caldas Santos Josue Carinhanha, de Assis Bastos Maria Lysete, de Araujo Junior Joao Xavier, do Nascimento Ticiano Gomes, Basilio Junior Irinaldo Diniz, Meireles Grillo Luciano Aparecido, Dornelas Camila Braga. Characterization and Stability of the Antimony-Quercetin Complex. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(3):432-438. Available from: https://sid.ir/paper/740182/en

    IEEE: Copy

    Valcilaine Teixeira Barbosa, Janaina Barros de Menezes, Josue Carinhanha Caldas Santos, Maria Lysete de Assis Bastos, Joao Xavier de Araujo Junior, Ticiano Gomes do Nascimento, Irinaldo Diniz Basilio Junior, Luciano Aparecido Meireles Grillo, and Camila Braga Dornelas, “Characterization and Stability of the Antimony-Quercetin Complex,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 3, pp. 432–438, 2019, [Online]. Available: https://sid.ir/paper/740182/en

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