An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds

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ROUSHANGAR ZINEH BABAK; SHABGARD MOHAMMAD REZA; ROSHANGAR LEILA

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Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:4 Page(s): 643-655

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Title

An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds

Author(s)

ROUSHANGAR ZINEH BABAK | SHABGARD MOHAMMAD REZA | ROSHANGAR LEILA | Issue Writer Certificate

Keywords

Halloysite nanotube

Alginate

Methylcellulose

Scaffold

Bioprint

WST assay

Abstract

Purpose: Cartilage shows neither repairs nor regenerative properties after trauma or gradual wear and causes severe pain due to bones rubbing. Bioprinting of tissue-engineered artificial cartilage is one of the most fast-growing sciences in this area that can help millions of people against this disease. Methods: Bioprinting of proper bioScaffolds for cartilage repair was the main goal of this study. The Bioprinting process was achieved by a novel composition consisting of Alginate (AL), Halloysite nanotube (HNT), and Methylcellulose (MC) prepared in bio-ink. Also, the effect of Russian olive (RO) in chondrocytes growth on bioScaffolds was also investigated in this work. Compressive, hardness and viscosity tests, Energy-Dispersive X-Ray Spectroscopy (EDX), Fourier-Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), water-soluble Tetrazolium (WST) assay, and also transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were carried out. Results: The results show that in constant concentrations of AL, MC, and RO (20 mg/ml AL, 20 mg/ml MC, and 10 mg/ml RO) when concentration of HNT increased from 10 mg/ml (T-7) to 20 mg/ml (T-8) compressive stiffness increased from 241± 45 kPa to 500. 66± 19. 50 kPa. Also, 20 mg/ml of AL in composition saved proper water content for chondrocyte growth and produced good viscosity properties for a higher printing resolution. Conclusion: RO increased chondrocytes living cell efficiency by 11% on Bioprinted Scaffolds in comparison with the control group without RO. Results obtained through invivo studies were similar to those of in-vitro studies. According to the results, T-7 bio-ink has good potential in Bioprinting of Scaffolds in cartilage repairs.

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APA: Copy

ROUSHANGAR ZINEH, BABAK, SHABGARD, MOHAMMAD REZA, & ROSHANGAR, LEILA. (2018). An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds. ADVANCED PHARMACEUTICAL BULLETIN, 8(4), 643-655. SID. https://sid.ir/paper/740200/en

Vancouver: Copy

ROUSHANGAR ZINEH BABAK, SHABGARD MOHAMMAD REZA, ROSHANGAR LEILA. An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(4):643-655. Available from: https://sid.ir/paper/740200/en

IEEE: Copy

BABAK ROUSHANGAR ZINEH, MOHAMMAD REZA SHABGARD, and LEILA ROSHANGAR, “An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 4, pp. 643–655, 2018, [Online]. Available: https://sid.ir/paper/740200/en

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