Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DANA NASIM; VASEGHI GOLNAZ; HAGHJOOY JAVANMARD SHAGHAYEGH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 12-21

Download Full-Text

View:

110

Download:

104

Cites:

Information Journal Paper

Title

Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review

Author(s)

DANA NASIM | VASEGHI GOLNAZ | HAGHJOOY JAVANMARD SHAGHAYEGH | Issue Writer Certificate

Keywords

Peroxisome proliferatoractivated receptor

Toll-like receptor

Interaction

Crosstalk

Abstract

As one of the four major families of pattern recognition receptors (PRRs), toll like receptors (TLRs) are crucial and important components of the innate immune system. Peroxisome proliferatoractivated receptors (PPARs) with three isoforms are transcription factors classified as a subfamily of nuclear receptor proteins, and are of significant regulatory activity in cellular differentiation, development, metabolism, and tumorigenesis. It is well established that PPARs agonists display anti-inflammatory effects through inhibition of the nuclear factor-kappa B (NF-κ B) pathway, a key regulator of immune and inflammatory responses, in a sense that TLRs signaling pathways are mainly toward activation of NF-κ B. Through a systematic review of previous studies, we aimed to address and clarify the reciprocal Interaction between TLRs and PPARs in hope to find alternative therapeutic approaches for inflammatory diseases. Among the available scientific database, 31 articles were selected for this review. A comprehensive review of this database confirms the presence of a cross-talk between PPARs and TLRs, indicating that not only PPARs stimulation may affect the expression level of TLRs via several mechanisms leading to modulating TLRs activities, but also TLRs have the potential to moderate the expression of PPARs. We, therefore, conclude that, as a key regulator of the innate immune system, the Interaction between PPARs and TLRs is a potential therapeutic target in disease treatment.

Cites

No record.

References

No record.

Cite

APA: Copy

DANA, NASIM, VASEGHI, GOLNAZ, & HAGHJOOY JAVANMARD, SHAGHAYEGH. (2019). Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 12-21. SID. https://sid.ir/paper/740227/en

Vancouver: Copy

DANA NASIM, VASEGHI GOLNAZ, HAGHJOOY JAVANMARD SHAGHAYEGH. Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):12-21. Available from: https://sid.ir/paper/740227/en

IEEE: Copy

NASIM DANA, GOLNAZ VASEGHI, and SHAGHAYEGH HAGHJOOY JAVANMARD, “Crosstalk between Peroxisome Proliferator-Activated Receptors and Toll-Like Receptors: A Systematic Review,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 12–21, 2019, [Online]. Available: https://sid.ir/paper/740227/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops