The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage

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MOSAFERI ELNAZ; Alizadeh Gharamaleki Nazila; FARZADI LAYA; MAJIDI JAFAR; BABALOO ZOHREH; KAZEMI TOHID; Ramezani Mehrnoosh; TABATABAEI MERAJ; AHMADI HAMID; AGHEBATI MALEKI LEILI; BARADARAN BEHZAD

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 70-75

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Title

The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage

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Keywords

HLA-G

Placenta

Real-time PCR

Miscarriage

Abstract

Purpose: Although it has been frequently confirmed that HLA-G plays an important role in the reproduction and pregnancy, the pattern of HLA-G gene and its protein expression are rarely addressed in studies. Therefore we conducted this study in regard to evaluate the HLA-G gene and its protein expression in the women’ s Placenta with recurrent Miscarriage. Methods: Placental samples were obtained from the women who were admitted for delivery or abortion in Al Zahra and Taleghani hospitals, Tabriz, Iran. HLA-G gene expression was determined by real-time polymerase chain reaction (PCR) and HLA-G protein expression was assessed by western blotting and immunofluorescence staining in the tissue samples. Results: The results showed a significant decrease in the expression of gene and proteins of HLA-G in the women with recurrent Miscarriage compared to the control Placental tissues. Conclusion: According to the obtained results, it was concluded that the decrement of HLA-G gene and protein expressions are associated with recurrent Miscarriage. Since there are conflicting results from other studies, it is suggested to conduct a more comprehensive similar study with greater sample size.

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APA: Copy

MOSAFERI, ELNAZ, Alizadeh Gharamaleki, Nazila, FARZADI, LAYA, MAJIDI, JAFAR, BABALOO, ZOHREH, KAZEMI, TOHID, Ramezani, Mehrnoosh, TABATABAEI, MERAJ, AHMADI, HAMID, AGHEBATI MALEKI, LEILI, & BARADARAN, BEHZAD. (2019). The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 70-75. SID. https://sid.ir/paper/740230/en

Vancouver: Copy

MOSAFERI ELNAZ, Alizadeh Gharamaleki Nazila, FARZADI LAYA, MAJIDI JAFAR, BABALOO ZOHREH, KAZEMI TOHID, Ramezani Mehrnoosh, TABATABAEI MERAJ, AHMADI HAMID, AGHEBATI MALEKI LEILI, BARADARAN BEHZAD. The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):70-75. Available from: https://sid.ir/paper/740230/en

IEEE: Copy

ELNAZ MOSAFERI, Nazila Alizadeh Gharamaleki, LAYA FARZADI, JAFAR MAJIDI, ZOHREH BABALOO, TOHID KAZEMI, Mehrnoosh Ramezani, MERAJ TABATABAEI, HAMID AHMADI, LEILI AGHEBATI MALEKI, and BEHZAD BARADARAN, “The Study of HLA-G Gene and Protein Expression in Patients with Recurrent Miscarriage,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 70–75, 2019, [Online]. Available: https://sid.ir/paper/740230/en

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