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Information Journal Paper

Title

Induction of traumatic brain and spinal cord injury models in rat using a modified impactor device

Pages

  228-239

Abstract

 Introduction: The use of standard rodent model, allows for the understanding of neuronal injury physiopathology and helping development of therapeutic strategies. Because of eliminating technical problems, we designed a Modified impactor device with ability to induce different degrees according to kilodyne from very mild to very severe of Spinal cord injury (SCI) and Traumatic brain injury (TBI) models in rat. Methods: For standardization and determining of optimal performance of the device to induce varying injuries, 47 adult male Wistar rats were used, and 8 different forces were applied in spinal cord and brain tissues. Results: The hematoxylin and eosin and 2, 3, 5-triphenyltetrazolium chloride (TTC) results demonstrated that by increasing the level of forces, histological changes in the spinal cord and brain were significantly enhanced. Different injuries had significant effect on the Basso-Beattie-Brenham and elevated body swing test outcomes, and there were significant differences between groups in comparison with control group. Conclusion: Our results showed that the modified device could be valid to produce precise SCI and TBI models, goal to replicate SCI and TBI in humans as much as possible. However, it might be considered that aspects of SCI and TBI models are complicate and more examination is necessary.

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    APA: Copy

    GHORBANI, MEYSAM, SHAHABI, PARVIZ, EBRAHIMI KALAN, ABBAS, Soltani Zangbar, Hamid, MAHMOUDI, JAVAD, BANI, SOHEILA, SADEGHZADEH OSKOUEI, BEHNAZ, Rafiee Byraami, Yusef, & Salimi, Omid. (2018). Induction of traumatic brain and spinal cord injury models in rat using a modified impactor device. PHYSIOLOGY AND PHARMACOLOGY, 22(4), 228-239. SID. https://sid.ir/paper/740467/en

    Vancouver: Copy

    GHORBANI MEYSAM, SHAHABI PARVIZ, EBRAHIMI KALAN ABBAS, Soltani Zangbar Hamid, MAHMOUDI JAVAD, BANI SOHEILA, SADEGHZADEH OSKOUEI BEHNAZ, Rafiee Byraami Yusef, Salimi Omid. Induction of traumatic brain and spinal cord injury models in rat using a modified impactor device. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2018;22(4):228-239. Available from: https://sid.ir/paper/740467/en

    IEEE: Copy

    MEYSAM GHORBANI, PARVIZ SHAHABI, ABBAS EBRAHIMI KALAN, Hamid Soltani Zangbar, JAVAD MAHMOUDI, SOHEILA BANI, BEHNAZ SADEGHZADEH OSKOUEI, Yusef Rafiee Byraami, and Omid Salimi, “Induction of traumatic brain and spinal cord injury models in rat using a modified impactor device,” PHYSIOLOGY AND PHARMACOLOGY, vol. 22, no. 4, pp. 228–239, 2018, [Online]. Available: https://sid.ir/paper/740467/en

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