Utility of Lubiprostone for Japanese Children with Functional Constipation

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FUJII YOSHIMITSU; Morimoto Tetsuji

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Paper Information

Journal: IRANIAN JOURNAL OF PEDIATRICS Year:2019 | Volume:29 | Issue:1 Page(s): 0-0

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Title

Utility of Lubiprostone for Japanese Children with Functional Constipation

Author(s)

FUJII YOSHIMITSU | Morimoto Tetsuji | Issue Writer Certificate

Keywords

Child

Functional Constipation

Gastrointestinal Motility-Regulating Agent

Lubiprostone

Nausea

Abstract

Introduction: Lubiprostone is considered as a useful laxative for functional constipation in adults. However, although lubiprostone is described in the Guideline of Pediatric Chronic Functional Constipation Treatment (Japanese), it has never been used as a pediatric medicine in Japan because there is no clinical usage experience in children. Here, the current research describes the first pediatric experience of lubiprostone in Japan, with a focus on measures against lubiprostone-induced nausea. Case Presentation: Lubiprostone 24- g capsules, 0. 38 to 1. 06 g/kg/time, were used with eight administrations in six patients with intractable functional constipation. All administrations improved defecation, fecal frequency, andthe Bristol stool scale score. Complete remission was obtained within four months in five patients (83. 3 %). Lubiprostone-induced nausea occurred in two administrations of greater than 0. 69 g/kg/time. However, a dose of 0. 90 g/kg/time with simultaneous administration of trimebutine maleate did not induce nausea in one repeat administration. Conclusions: Lubiprostone is useful for intractable functional constipation in children.

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APA: Copy

FUJII, YOSHIMITSU, & Morimoto, Tetsuji. (2019). Utility of Lubiprostone for Japanese Children with Functional Constipation. IRANIAN JOURNAL OF PEDIATRICS, 29(1), 0-0. SID. https://sid.ir/paper/740612/en

Vancouver: Copy

FUJII YOSHIMITSU, Morimoto Tetsuji. Utility of Lubiprostone for Japanese Children with Functional Constipation. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2019;29(1):0-0. Available from: https://sid.ir/paper/740612/en

IEEE: Copy

YOSHIMITSU FUJII, and Tetsuji Morimoto, “Utility of Lubiprostone for Japanese Children with Functional Constipation,” IRANIAN JOURNAL OF PEDIATRICS, vol. 29, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/740612/en

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