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Information Journal Paper

Title

A Study on the Presence of Osteopontin and α 3β 1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation

Pages

  87-93

Abstract

 Background: Embryo implantation is a critical and multifactorial phenomenon which can be affected by any alteration in molecular micro construction of Endometrium. The aim of the current study was to evaluate the effects of diabetes on Osteopontin (OPN) and α 3β 1 integrin proteins level at the time of endometrial receptivity. Methods: Twenty-eight female rats were divided into control, diabetic, pioglitazonetreated and metformin-treated groups. Western blot was performed to determine the OPN and α 3β 1 integrin proteins in rats’ Endometrium at the time of implantation. Data were analyzed by analysis of variance (ANOVA) and p<0. 05 was considered statistically significant. Results: OPN increased significantly in the diabetic group in comparison with control (p<0. 001), metformin-treated (p=0. 008) and pioglitazone-treated groups (p< 0. 001). Furthermore, α 3β 1 integrin protein level in diabetic group had a significant difference in comparison with that of the control (p<0. 001), metformin-treated (p= 0. 026) and pioglitazone-treated groups (p<0. 001). Conclusion: OPN and α 3β 1 integrin proteins are involved in embryo implantation and their changes in diabetic condition can affect fertility. Treatment with pioglitazone and metformin improved the level of OPN and α 3β 1 integrin proteins while pioglitazone was more effective.

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    Cite

    APA: Copy

    ZARRIN, YASAMAN, Bakhteyari, Abbas, MOSTAFAVI, FATEMEH SADAT, ESKANDARI, NAHID, MATINFAR, MOHAMMAD, & ABOUTORABI, ROSHANAK. (2020). A Study on the Presence of Osteopontin and α 3β 1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation. JOURNAL OF REPRODUCTION AND INFERTILITY, 21(2), 87-93. SID. https://sid.ir/paper/741048/en

    Vancouver: Copy

    ZARRIN YASAMAN, Bakhteyari Abbas, MOSTAFAVI FATEMEH SADAT, ESKANDARI NAHID, MATINFAR MOHAMMAD, ABOUTORABI ROSHANAK. A Study on the Presence of Osteopontin and α 3β 1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2020;21(2):87-93. Available from: https://sid.ir/paper/741048/en

    IEEE: Copy

    YASAMAN ZARRIN, Abbas Bakhteyari, FATEMEH SADAT MOSTAFAVI, NAHID ESKANDARI, MOHAMMAD MATINFAR, and ROSHANAK ABOUTORABI, “A Study on the Presence of Osteopontin and α 3β 1 Integrin in the Endometrium of Diabetic Rats at the Time of Embryo Implantation,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 21, no. 2, pp. 87–93, 2020, [Online]. Available: https://sid.ir/paper/741048/en

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