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Information Journal Paper

Title

Prevalence of Cytomegalovirus in Semen of Male Partners of Infertile Couples and the Virus Impact on Sperm Parameters

Pages

  124-129

Abstract

 Background: Genital tract infection is one of the causes of Male infertility. Several studies have shown a role for human Cytomegalovirus (CMV) in this context. In the present study, the prevalence of CMV in a population of male partners of infertile couples was estimated and the impact of CMV on sperm parameters was determined. Methods: In this cross sectional study, CMV DNA and virus copy number were examined in the semen of 150 participants including 80 with normal Semen analysis (SA) and 70 with abnormal SA, by quantitative Real-Time PCR. Sperm parameters were compared between CMV positive and negative groups. Comparisons with pvalues under 0. 05 were considered significant. Logistic regression was performed to control the effect of some variables with p<0. 25 on sperm parameters. Results: CMV DNA was detected in the semen of 28 (18. 6%) individuals. 21 men (30%) with abnormal SA and 7 (8. 8%) with normal SA were positive for CMV DNA (p=0. 001). The mean virus copy number was 883. 1± 4662. 01 for the men with abnormal SA and 2525. 7± 12680. 9 for those with normal SA (p=0. 001). Sperm count was (32. 1± 23. 5) x106 in CMV positive and (44. 2± 24. 1) x106 in CMV negative groups (p=0. 022). Normal sperm morphology was 2. 73± 2. 83% and 5. 99± 5. 44% in CMV positive and negative groups, respectively (p<0. 001). After controlling some variables, the sperm morphology remains the only statistically significant sperm parameter that was reduced by CMV. Conclusion: The higher CMV prevalence in the semen of males with abnormal SA compared to normal SA and significant reduction of sperm morphology in the presence of CMV, are in favor of the negative impact of CMV on male fertility.

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    APA: Copy

    NAMAVAR JAHROMI, BAHIA, Yaghobi, Ramin, Matlub, Najmeh, Fazelzadeh, Arezou, Ramzi, Abolfazl, ANVAR, ZAHRA, ZARE, NAJAF, SALARIAN, LEILA, & FALLAHI, JAFAR. (2020). Prevalence of Cytomegalovirus in Semen of Male Partners of Infertile Couples and the Virus Impact on Sperm Parameters. JOURNAL OF REPRODUCTION AND INFERTILITY, 21(2), 124-129. SID. https://sid.ir/paper/741049/en

    Vancouver: Copy

    NAMAVAR JAHROMI BAHIA, Yaghobi Ramin, Matlub Najmeh, Fazelzadeh Arezou, Ramzi Abolfazl, ANVAR ZAHRA, ZARE NAJAF, SALARIAN LEILA, FALLAHI JAFAR. Prevalence of Cytomegalovirus in Semen of Male Partners of Infertile Couples and the Virus Impact on Sperm Parameters. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2020;21(2):124-129. Available from: https://sid.ir/paper/741049/en

    IEEE: Copy

    BAHIA NAMAVAR JAHROMI, Ramin Yaghobi, Najmeh Matlub, Arezou Fazelzadeh, Abolfazl Ramzi, ZAHRA ANVAR, NAJAF ZARE, LEILA SALARIAN, and JAFAR FALLAHI, “Prevalence of Cytomegalovirus in Semen of Male Partners of Infertile Couples and the Virus Impact on Sperm Parameters,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 21, no. 2, pp. 124–129, 2020, [Online]. Available: https://sid.ir/paper/741049/en

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