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Information Journal Paper

Title

Increased expression of PD-1 on CD4+ T cells subsets in Rheumatoid Arthritis patients

Pages

  61-70

Keywords

CD4+CD28+ T cells 
CD4+CD28-T cells 

Abstract

 Background and objectives: Rheumatoid Arthritis (RA) is a common chronic and systemic autoimmune disease, characterized by inflammation and the destruction of the joints. It is well known that CD4+ T cells play a major role in the pathogenesis of RA. Expanded subpopulations of CD4+ T cells have been reported in RA patients. Here, we investigated the expression of PD-1 on subsets of CD4+ T cells (CD4+CD28-and CD4+CD28+ T cells) in the peripheral blood (PB) and synovial fluid (SF) of patients with RA. Methods: A total of 42 RA patients, including 10 newly diagnosed (ND) and 32 relapsed (RL) cases and also 20 healthy controls were enrolled. Phenotypic characterization subsets of CD4+ T cells were evaluated by flow cytometry, using fluorescence conjugated specific human monoclonal antibodies. Results: The frequency of CD4+CD28+ T cells was significantly increased in SF versus PB in ND and RL patients. In contrast, the percentage of CD4+CD28-T cells was elevated in PB of ND and RL patients comparison to SF. Expression of PD-1 on CD4+CD28+ and CD4+CD28-T cells in PB of ND and RL patients was significantly higher than the healthy controls. Furthermore, PD-1 expression on CD4+CD28+ and CD4+CD28-T cells in SF versus PB of RL patients were significant increased. Conclusion: These data suggest that CD4+ T cells subsets in RA patients were resistance to PD-1 mediated effects and PD-1 has insufficient ability to suppression of CD4+Tcells.

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    • References

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    APA: Copy

    Ajam, Faezeh, AGHAEI, MEHRDAD, MOHAMMADI, SAEED, SAEEDI, MOHSEN, BEHNAMPOUR, NASSER, & MEMARIAN, ALI. (2019). Increased expression of PD-1 on CD4+ T cells subsets in Rheumatoid Arthritis patients. JORJANI BIOMEDICINE JOURNAL, 7(2), 61-70. SID. https://sid.ir/paper/741136/en

    Vancouver: Copy

    Ajam Faezeh, AGHAEI MEHRDAD, MOHAMMADI SAEED, SAEEDI MOHSEN, BEHNAMPOUR NASSER, MEMARIAN ALI. Increased expression of PD-1 on CD4+ T cells subsets in Rheumatoid Arthritis patients. JORJANI BIOMEDICINE JOURNAL[Internet]. 2019;7(2):61-70. Available from: https://sid.ir/paper/741136/en

    IEEE: Copy

    Faezeh Ajam, MEHRDAD AGHAEI, SAEED MOHAMMADI, MOHSEN SAEEDI, NASSER BEHNAMPOUR, and ALI MEMARIAN, “Increased expression of PD-1 on CD4+ T cells subsets in Rheumatoid Arthritis patients,” JORJANI BIOMEDICINE JOURNAL, vol. 7, no. 2, pp. 61–70, 2019, [Online]. Available: https://sid.ir/paper/741136/en

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