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Information Journal Paper

Title

Analysis of a Preimplantation Genetic Test for Aneuploidies in Embryos from Colombian Couples: A Report of Cases

Pages

  17-33

Keywords

Assisted reproduction techniques (ARTs) 
Preimplantation genetic test for aneuploidies (PGT-A) 

Abstract

 Background: Assisted reproduction techniques (ARTs) and the preimplantation genetic test for aneuploidies (PGT-A) help couples with fertility problems to achieve a healthy live birth around the world. The aim of this study was to determine the rate of whole chromosomal Copy number variations in embryos from couples undergoing ART and PGT-A, associations of chromosomal variations with embryo morphological parameters, and their relationship to maternal age. Methods: This study included a retrospective analysis of the number of whole chromosomal copies identified by aCGH in embryos from couples undergoing ART. Results: Seventy-six embryos from 29 couples using their own gametes were analyzed, of which 25 (32. 9%) were chromosomally normal, and 51 (67. 1%) were abnormal. Eleven embryos were evaluated from the group of couples with donated gametes, of which 5 (45. 4%) embryos were chromosomally normal, and 6 (54. 5%) embryos were abnormal. The main aneuploidies observed were trisomy X (7. 8%), trisomy 21 (5. 9%), trisomy 9 (3. 9%), monosomy 11 (3. 9%), monosomy 13 (3. 9%) and monosomy X (3. 9%), and the principal chromosomes affected were 19, X and 13. A significant association was found between the quality of the embryo and the genetic condition: embryos with euploidy and aneuploidy (p=0. 046). Conclusion: The rate of aneuploidies from couples with their own gametes was 67. 1% (51/76) and from couples with donated eggs and/or sperm was 54. 5% (6/11). The quality of the embryo determinated by the morphological parameters was not associated with the embryo genetic status, and also there was no association between maternal age and aneuploidy rate.

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    APA: Copy

    Cardenas Nieto, Diana, Forero Castro, Maribel, Moreno Ortiz, Harold, Lucena Quevedo, Elkin, Cuzzi, Juliana, & Esteban Perez, Clara. (2020). Analysis of a Preimplantation Genetic Test for Aneuploidies in Embryos from Colombian Couples: A Report of Cases. JOURNAL OF REPRODUCTION AND INFERTILITY, 21(1), 17-33. SID. https://sid.ir/paper/741417/en

    Vancouver: Copy

    Cardenas Nieto Diana, Forero Castro Maribel, Moreno Ortiz Harold, Lucena Quevedo Elkin, Cuzzi Juliana, Esteban Perez Clara. Analysis of a Preimplantation Genetic Test for Aneuploidies in Embryos from Colombian Couples: A Report of Cases. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2020;21(1):17-33. Available from: https://sid.ir/paper/741417/en

    IEEE: Copy

    Diana Cardenas Nieto, Maribel Forero Castro, Harold Moreno Ortiz, Elkin Lucena Quevedo, Juliana Cuzzi, and Clara Esteban Perez, “Analysis of a Preimplantation Genetic Test for Aneuploidies in Embryos from Colombian Couples: A Report of Cases,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 21, no. 1, pp. 17–33, 2020, [Online]. Available: https://sid.ir/paper/741417/en

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