Cost-Effectiveness Analysis of Topiramate versus Phenobarbital in the Treatment of Children with Febrile Seizure

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NEMATI HAMID; TALEBIANPOUR Hamid; LOTFI FARHAD; SEPEHRI Nazanin Zahra; KESHAVARZ KHOSRO

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Journal: Iranian Journal of Child Neurology Year:2019 | Volume:13 | Issue:4 Page(s): 109-120

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Title

Cost-Effectiveness Analysis of Topiramate versus Phenobarbital in the Treatment of Children with Febrile Seizure

Author(s)

Keywords

Febrile seizure

Topiramate

Phenobarbital

Costeffectiveness

Cost-utility

Abstract

Objectives Febrile seizure is common disorder in childhood, with a prevalence of 2% to 5%. There are many drugs for treatment of this disease; however, the most common prescribed medication in Iran is Phenobarbital that is cheap, but it has many side effects. We aimed to compare the Costeffectiveness of Topiramate versus Phenobarbital in patients with Febrile seizure in the south of Iran. Materials & Methods This econometric cost-effectiveness and Cost-utility study were conducted on 91 patients with Febrile seizure to assess two strategies of oral drug therapy including Phenobarbital and Topiramate in 2016-2017. Of all, 51 patients were treated with Phenobarbital and 40 patients received Topiramate. We followed up the patients for six months, using a randomized and single-blinded approach. A decision tree model was used. The outcomes of the model included Febrile seizure and utility. The study was conducted from the perspective of the community; therefore, direct and indirect costs were included in the study. Excel and Tree Age software (2011) were used to analyze the results. Results Topiramate was cheaper and more effective than Phenobarbital. In patients in the Phenobarbital and Topiramate groups, the mean costs were $740 and $674 per PPP, utility scores were 0. 72 and 0. 82, and Febrile seizure without side effects were 0. 3 and 0. 6, respectively. Moreover, one-way sensitivity analysis confirmed the robustness of the results of the study. Conclusion Topiramate in patients with Febrile seizure is a fully cost-effective and cost-efficient strategy suggested as a better alternative for children with Febrile seizure.

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APA: Copy

NEMATI, HAMID, TALEBIANPOUR, Hamid, LOTFI, FARHAD, SEPEHRI, Nazanin Zahra, & KESHAVARZ, KHOSRO. (2019). Cost-Effectiveness Analysis of Topiramate versus Phenobarbital in the Treatment of Children with Febrile Seizure. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 13(4), 109-120. SID. https://sid.ir/paper/741540/en

Vancouver: Copy

NEMATI HAMID, TALEBIANPOUR Hamid, LOTFI FARHAD, SEPEHRI Nazanin Zahra, KESHAVARZ KHOSRO. Cost-Effectiveness Analysis of Topiramate versus Phenobarbital in the Treatment of Children with Febrile Seizure. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2019;13(4):109-120. Available from: https://sid.ir/paper/741540/en

IEEE: Copy

HAMID NEMATI, Hamid TALEBIANPOUR, FARHAD LOTFI, Nazanin Zahra SEPEHRI, and KHOSRO KESHAVARZ, “Cost-Effectiveness Analysis of Topiramate versus Phenobarbital in the Treatment of Children with Febrile Seizure,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 13, no. 4, pp. 109–120, 2019, [Online]. Available: https://sid.ir/paper/741540/en

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