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Information Journal Paper

Title

In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes

Pages

  1970-1976

Abstract

 Background: Dermatophytosis is one of the most common fungal infections in humans. Antifungals such as Fluconazole are effectively used for treating dermatophytosis; however, drug resistance was observed in many cases. Therefore, a newer treatment strategy is essential. Methods: This study (Conducted in the Laboratory of the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran in 2018) evaluated the antifungal susceptibility of nano Fluconazole compared to conventional Fluconazole on Dermatophyte isolates using CLSI M38-A2guidelines. Dermatophyte species isolated from clinical cases of dermatophytosis were identified using PCR sequencing techniques. Zeta potential and size of the nano particles containing Fluconazole were measured; scanning electron microscope (SEM) was used to determine nano particle structure. Results: The size of liposomal Fluconazole obtained was 88. 9 12. 14 nm with – 20. 12 3. 8 mV for zeta potential. The encapsulation rate for Fluconazole was 75. 1 4. 2%. MIC50 for the three tested species was 32, 16, and 8 μ g/ml for Trichophyton interdigitale, T. rubrum, and Epidermophyton floccosum isolates, respectively. The corresponding values for nano Fluconazole were 8 μ g/ml for the three tested species. Conclusion: MIC value for nano-Fluconazole was lower than conventional Fluconazole in all Dermatophytes species tested; therefore, nano-Fluconazole could inhibit the growth of Dermatophytes better than Fluconazole at a lower concentration of the drug.

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    • Cite

    APA: Copy

    MUSAVI BAFRUI, Najmossadat, Hashemi Hazaveh, Seyed Jamal, & BAYAT, MANSOUR. (2020). In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes. IRANIAN JOURNAL OF PUBLIC HEALTH, 49(10), 1970-1976. SID. https://sid.ir/paper/741594/en

    Vancouver: Copy

    MUSAVI BAFRUI Najmossadat, Hashemi Hazaveh Seyed Jamal, BAYAT MANSOUR. In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2020;49(10):1970-1976. Available from: https://sid.ir/paper/741594/en

    IEEE: Copy

    Najmossadat MUSAVI BAFRUI, Seyed Jamal Hashemi Hazaveh, and MANSOUR BAYAT, “In-Vitro Activity of Nano Fluconazole and Conventional Flucon-azole against Clinically Important Dermatophytes,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 49, no. 10, pp. 1970–1976, 2020, [Online]. Available: https://sid.ir/paper/741594/en

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