Transfusion Medicine and Molecular Genetic Methods (Review Article)

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Saleh Rozieyati Mohamed; Zefarina Zulkafli; Che Mat Nor Fazila; Chambers Geoffrey Keith; Edinur Hisham Atan

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Journal Paper

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Journal: International Journal of Preventive Medicine Year:2018 | Volume:9 | Issue:- Page(s): 0-0

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Title

Transfusion Medicine and Molecular Genetic Methods (Review Article)

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Keywords

Blood groups

genetic marker

human platelet antigen and human leukocyte antigen

transfusion

Abstract

transfusion procedures are always complicated by potential genetic mismatching between donor and recipient. Compatibility is determined by several major antigens, such as the ABO and Rhesus Blood groups. Matching for other Blood groups (Kell, Kidd, Duffy, and MNS), human platelet antigens, and human leukocyte antigens (HLAs) also contributes toward the successful transfusion outcomes, especially in multitransfused or highly immunized patients. All these antigens of tissue identity are highly polymorphic and thus present great challenges for finding suitable donors for transfusion patients. The ABO blood group and HLA markers are also the determinants of transplant compatibility, and mismatched antigens will cause graft rejection or graft‑ versus‑ host disease. Thus, a single and comprehensive registry covering all of the significant transfusion and transplantation antigens is expected to become an important tool in providing an efficient service capable of delivering safe blood and quickly locating matching organs/stem cells. This review article is intended as an accessible guide for physicians who care for transfusion‑ dependent patients. In particular, it serves to introduce the new molecular screening methods together with the biology of these systems, which underlies the tests.

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APA: Copy

Saleh, Rozieyati Mohamed, Zefarina, Zulkafli, Che Mat, Nor Fazila, Chambers, Geoffrey Keith, & Edinur, Hisham Atan. (2018). Transfusion Medicine and Molecular Genetic Methods (Review Article). INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 9(-), 0-0. SID. https://sid.ir/paper/742096/en

Vancouver: Copy

Saleh Rozieyati Mohamed, Zefarina Zulkafli, Che Mat Nor Fazila, Chambers Geoffrey Keith, Edinur Hisham Atan. Transfusion Medicine and Molecular Genetic Methods (Review Article). INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2018;9(-):0-0. Available from: https://sid.ir/paper/742096/en

IEEE: Copy

Rozieyati Mohamed Saleh, Zulkafli Zefarina, Nor Fazila Che Mat, Geoffrey Keith Chambers, and Hisham Atan Edinur, “Transfusion Medicine and Molecular Genetic Methods (Review Article),” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 9, no. -, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/742096/en

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