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Information Journal Paper

Title

The Effect of N-Acetyl-Cysteine on NRF2 Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study

Author(s)

 Jannatifar Rahil | PARIVAR KAZEM | HAYATI ROODBARI NASIM | NASR ESFAHANI MOHAMMAD HOSSEIN | Issue Writer Certificate 

Pages

  171-175

Abstract

 Background: One of the important factor associated with male infertility is high production of reactive oxygen species (ROS). The main function of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) is to activate the cellular antioxidant response by inducing the transcription of a wide array of genes that can combat the harmful effects of factors such as Oxidative Stress. The purpose of this study was to evaluate the effect of N-acetyl-L-cysteine (NAC), as an antioxidant drug, on NRF2 Gene Expression in Asthenoteratozoospermia Men. Materials and Methods: In this randomized, blinded clinical trial study, included 50 infertile men with asthenoteratozoospermia, who received NAC (600 mg, three times daily). Sperm parameters analyzed according to the world health organization (WHO; 2010). Sperm DNA fragmentation, relative NRF2 expression, and seminal plasma level of antioxidant enzymes were measured by TUNEL assay, reverse transcription polymerase chain reaction (RT-PCR) and ELISA test, respectively. Results: After NAC treatment, findings showed a significant increase in sperm concentration and motility compared to pre-treatment status, whereas the percentage of abnormal morphology and DNA fragmentation was significantly decreased (P<0. 05). A significant improvement in expression of NRF2 gene and antioxidant enzyme levels were observed compared to pre-treatment by NAC (P<0. 05). Significant correlations were observed between NRF2 mRNA expression level, specific sperm parameters and level of antioxidant enzymes (P<0. 05). Conclusion: The results demonstrated that NAC oral supplementation protected against Oxidative Stress by enhancing NRF2 expression. This could improve semen parameters quality parameters in asthenoteratozoospermia men.

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    APA: Copy

    Jannatifar, Rahil, PARIVAR, KAZEM, HAYATI ROODBARI, NASIM, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2020). The Effect of N-Acetyl-Cysteine on NRF2 Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 14(3), 171-175. SID. https://sid.ir/paper/742106/en

    Vancouver: Copy

    Jannatifar Rahil, PARIVAR KAZEM, HAYATI ROODBARI NASIM, NASR ESFAHANI MOHAMMAD HOSSEIN. The Effect of N-Acetyl-Cysteine on NRF2 Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2020;14(3):171-175. Available from: https://sid.ir/paper/742106/en

    IEEE: Copy

    Rahil Jannatifar, KAZEM PARIVAR, NASIM HAYATI ROODBARI, and MOHAMMAD HOSSEIN NASR ESFAHANI, “The Effect of N-Acetyl-Cysteine on NRF2 Antioxidant Gene Expression in Asthenoteratozoospermia Men: A Clinical Trial Study,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 14, no. 3, pp. 171–175, 2020, [Online]. Available: https://sid.ir/paper/742106/en

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