EVALUATION THE αSMA POSITIVE MYOFIBROBLASTS IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL EPITHELIAL DYSPLASIA AND HYPERKERATOSIS

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SEYFI SAFOURA; SHAFAHI SH.; SHAFIGH E.; SAHABI S.M.; GHASEMI HAMID REZA

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Journal: Journal of Mashhad Dental School Year:2010 | Volume:33 | Issue:4 (71) Page(s): 321-330

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Title

EVALUATION THE αSMA POSITIVE MYOFIBROBLASTS IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL EPITHELIAL DYSPLASIA AND HYPERKERATOSIS

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Keywords

SQUAMOUS CELL CARCINOMAQ2

DYSPLASIAQ2

HYPERKERATOSISQ3

ALPHA SMA PROTEINQ3

Abstract

Introduction: Tumoral stroma has a main role in gross and aggressive behavior of different neoplasms. Myofibroblasts are key cells in stroma and in carcinogenesis process. The purpose of this study was immunochistochemistry evaluation of myofibroblasts in oral SQUAMOUS CELL CARCINOMA (SCC) compared with oral epithelial DYSPLASIA and HYPERKERATOSIS in carcinogenesis process.Materials & Methods: In this descriptive cross sectional study 18 paraffinized blocks of Oral SQUAMOUS CELL CARCINOMA (OSCC), 18 samples of oral epithelial DYSPLASIA and, 18 samples of HYPERKERATOSIS and five normalflora samples were immunostained for alpha SMA detection. Number of aSMA positive myofibroblasts in 100 cells (x40) was evaluated.Results were reported as the percent of immunostained cells. Statistical tests included Kruskal-Wallis, ANOVA and Chi-Square test.Results: In OSCC, 8 cases had score3 (++) and 4 cases had score2 (+). In epithelial DYSPLASIA, one case had Score3 (++) and 3 cases had score2 (+). Score2 (+) was showed in one case of HYPERKERATOSIS. aSMA detection was observed just in vascular endothelium of oral normal mucosa. Significance difference was found in alpha SMA positive myofibroblsts among OSCC, epithelial DYSPLASIA and HYPERKERATOSIS (P=0.000).Conclusion: Number (percent) of alpha SMA positive myofibroblasts increase in carcinogenesis process which could approve their role in tumoral invasive behavior.

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APA: Copy

SEYFI, SAFOURA, SHAFAHI, SH., SHAFIGH, E., SAHABI, S.M., & GHASEMI, HAMID REZA. (2010). EVALUATION THE αSMA POSITIVE MYOFIBROBLASTS IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL EPITHELIAL DYSPLASIA AND HYPERKERATOSIS. JOURNAL OF MASHHAD DENTAL SCHOOL, 33(4 (71)), 321-330. SID. https://sid.ir/paper/74322/en

Vancouver: Copy

SEYFI SAFOURA, SHAFAHI SH., SHAFIGH E., SAHABI S.M., GHASEMI HAMID REZA. EVALUATION THE αSMA POSITIVE MYOFIBROBLASTS IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL EPITHELIAL DYSPLASIA AND HYPERKERATOSIS. JOURNAL OF MASHHAD DENTAL SCHOOL[Internet]. 2010;33(4 (71)):321-330. Available from: https://sid.ir/paper/74322/en

IEEE: Copy

SAFOURA SEYFI, SH. SHAFAHI, E. SHAFIGH, S.M. SAHABI, and HAMID REZA GHASEMI, “EVALUATION THE αSMA POSITIVE MYOFIBROBLASTS IN ORAL SQUAMOUS CELL CARCINOMA AND ORAL EPITHELIAL DYSPLASIA AND HYPERKERATOSIS,” JOURNAL OF MASHHAD DENTAL SCHOOL, vol. 33, no. 4 (71), pp. 321–330, 2010, [Online]. Available: https://sid.ir/paper/74322/en

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