مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

189
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

84
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice

Pages

  283-289

Abstract

 Background: Erythrocytes require an ability to deform and withstand shear stress while negotiating microcirculation. These properties are largely due to their excess surface area per volume and the characteristics of the membrane’ s protein. Deficiencies of these proteins are associated with chronic hemolysis. Methods: This was a cross-sectional study aimed at determining the prevalence of red cell membrane protein abnormalities as determined by sodium dodecyl sulphate polyacrilamide gel electrophoresis (SDS-PAGE) among patients with anemia attending the outpatient clinics of the hospital. Results: A total of 823 participants were recruited into the study with a mean age of 34± 14 years. There were 410 (49. 8%) participants with hematocrit ≥ 36% and 413 with hematocrit ≤ 35. 9% of which 192 participants (23. 3%) had abnormal red cell indices. Following SDS-PAGE, 21 (10. 9%) of the 192 participants had deficient PAGE tracing. Abnormal spectrin band was observed in 17 (81%) of the 21 participants. The hematocrit was significantly lower while the reticulocyte count and red cell distribution width were higher in participants with red cell membrane abnormalities. Conclusion: One in ten patients with mild anemia and abnormal red cell indices in clinical practice may be having hereditary red cell membrane protein defect. Presence of raised reticulocyte count, family history of mild anemia, increased red cell distribution width and red cell morphology may be used to screen for membrane deficiency.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    DOSUNMU, ADEDOYIN, Uche, Ebele, OSIKOMAIYA, BODUNRIN, Ismail, Ayobami, AKINBAMI, AKINSEGUN, & Akanmu, Alani. (2020). Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice. CASPIAN JOURNAL OF INTERNAL MEDICINE, 11(3), 283-289. SID. https://sid.ir/paper/745391/en

    Vancouver: Copy

    DOSUNMU ADEDOYIN, Uche Ebele, OSIKOMAIYA BODUNRIN, Ismail Ayobami, AKINBAMI AKINSEGUN, Akanmu Alani. Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2020;11(3):283-289. Available from: https://sid.ir/paper/745391/en

    IEEE: Copy

    ADEDOYIN DOSUNMU, Ebele Uche, BODUNRIN OSIKOMAIYA, Ayobami Ismail, AKINSEGUN AKINBAMI, and Alani Akanmu, “Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 11, no. 3, pp. 283–289, 2020, [Online]. Available: https://sid.ir/paper/745391/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button