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Title

Interleukin-17A Genetic Polymorphisms as a Prognostic Markers for Resistence to Visceral Leishamniasis in the Iranian Population

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Abstract

 Background: Interleukin-17A (IL-17A) gene can be a potential candidate gene implicated in Visceral Leishmaniasis (VL), a disease caused by an infection with Leishmania parasite. Objectives: The aim of this study was to explore whether there is an association between IL-17A Polymorphisms and VL in the Iranian population. Methods: A total of 202 participants (55 VL patients and 125 healthy controls) were investigated in the present case-control study. Genotyping was performed using the polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP). Results: The frequencies of IL-17A rs3819024, rs3819025, and rs8193038 A alleles, and haplotype AGAG were signifi cantly higher in the controls than patients (P = 0. 0006, 0. 017, 0. 0003 and 0. 001, respectively), while IL-17A rs3748067 A allele distribution was higher in patients than controls (P = 0. 00004). Also, the frequencies of AA genotypes of rs3819024, rs3819025 and rs8193038 were higher in the controls (P = 0. 0048, 0. 014, and 0. 018, respectively) while rs3748067 AA genotype was of greater distribution in the patients (P = 0. 000048). Conclusions: The fi ndings highlighted the role of IL-17A in the pathogenesis of the VL in humans.

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    APA: Copy

    RASOULI, MANOOCHEHR, MOAZAMIAN, ELHAM, NASIRI, MAHBOOBEH, KESHAVARZ, MARYAM, & ASAEI, SADAF. (2019). Interleukin-17A Genetic Polymorphisms as a Prognostic Markers for Resistence to Visceral Leishamniasis in the Iranian Population. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 14(2), 0-0. SID. https://sid.ir/paper/745424/en

    Vancouver: Copy

    RASOULI MANOOCHEHR, MOAZAMIAN ELHAM, NASIRI MAHBOOBEH, KESHAVARZ MARYAM, ASAEI SADAF. Interleukin-17A Genetic Polymorphisms as a Prognostic Markers for Resistence to Visceral Leishamniasis in the Iranian Population. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2019;14(2):0-0. Available from: https://sid.ir/paper/745424/en

    IEEE: Copy

    MANOOCHEHR RASOULI, ELHAM MOAZAMIAN, MAHBOOBEH NASIRI, MARYAM KESHAVARZ, and SADAF ASAEI, “Interleukin-17A Genetic Polymorphisms as a Prognostic Markers for Resistence to Visceral Leishamniasis in the Iranian Population,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 14, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/745424/en

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