Effect of myricetin on the gene expressions of NOX3, TGF-β 1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats

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BAHALOO MARYAM; REZVANI MOHAMMAD EBRAHIM; FARASHAHI YAZD EHSAN; ZAREH MEHRJERDI FATEMEH; DAVARI MOHAMMAD HOSSEIN; ROOHBAKHSH ALI; MOLLASADEGHI ABOLFAZL; Nikkhah Haniyeh; VAFAEI MARYAM; MEHRPARVAR AMIR HOUSHANG

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Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:5 Page(s): 594-599

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Title

Effect of myricetin on the gene expressions of NOX3, TGF-β 1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats

Author(s)

Keywords

Anti-oxidants

Gene expression

Myricetin

NADPH oxidase

Noise-induced hearing loss

Superoxide dismutase

Abstract

Objective(s): Noise-induced hearing loss is one of the most common occupational diseases in industrialized countries and can be affected by various environmental and genetic factors. This study was designed to examine the effect of Myricetin in preventing this disorder. Materials and Methods: Twenty-one Wistar rats were randomly divided into five groups: Non-exposed, noise exposure only, noise exposure with vehicle, noise exposure with Myricetin 5 mg/Kg, and noise exposure with Myricetin 10 mg/kg. All animals were sacrificed after last noise exposure. The left cochlea was dissected from each rat. It was used for mRNA expression analysis (NOX3, TGF-β 1, prestin, and HSP-70). Blood samples were collected to assess Superoxide dismutase (SOD) activity, 1, 1 diphenyl picrylhydrazyl (DPPH), and malondialdehyde (MDA) measurements. Results: Real time-PCR assay revealed that noise decreased NOX3 and increased TGF-β 1, prestin, and HSP-70 Gene expressions. Administration of Myricetin at the dose of 5 mg/kg, but not at 10 mg/kg, significantly reversed these changes. Noise also increased MDA levels and decreased SOD and DPPH scavenging activities. Myricetin at the doses of 5 and 10 mg/kg also reversed these changes. Conclusion: The findings of this study showed that Myricetin at the dose of 5 mg/Kg was able to reverse noise-induced abnormalities in Gene expression and oxidant/anti-oxidant balance. It is a possibility that Myricetin via enhancement of anti-oxidant activity induced these effects.

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APA: Copy

BAHALOO, MARYAM, REZVANI, MOHAMMAD EBRAHIM, FARASHAHI YAZD, EHSAN, ZAREH MEHRJERDI, FATEMEH, DAVARI, MOHAMMAD HOSSEIN, ROOHBAKHSH, ALI, MOLLASADEGHI, ABOLFAZL, Nikkhah, Haniyeh, VAFAEI, MARYAM, & MEHRPARVAR, AMIR HOUSHANG. (2020). Effect of myricetin on the gene expressions of NOX3, TGF-β 1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(5), 594-599. SID. https://sid.ir/paper/745441/en

Vancouver: Copy

BAHALOO MARYAM, REZVANI MOHAMMAD EBRAHIM, FARASHAHI YAZD EHSAN, ZAREH MEHRJERDI FATEMEH, DAVARI MOHAMMAD HOSSEIN, ROOHBAKHSH ALI, MOLLASADEGHI ABOLFAZL, Nikkhah Haniyeh, VAFAEI MARYAM, MEHRPARVAR AMIR HOUSHANG. Effect of myricetin on the gene expressions of NOX3, TGF-β 1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(5):594-599. Available from: https://sid.ir/paper/745441/en

IEEE: Copy

MARYAM BAHALOO, MOHAMMAD EBRAHIM REZVANI, EHSAN FARASHAHI YAZD, FATEMEH ZAREH MEHRJERDI, MOHAMMAD HOSSEIN DAVARI, ALI ROOHBAKHSH, ABOLFAZL MOLLASADEGHI, Haniyeh Nikkhah, MARYAM VAFAEI, and AMIR HOUSHANG MEHRPARVAR, “Effect of myricetin on the gene expressions of NOX3, TGF-β 1, prestin, and HSP-70 and anti-oxidant activity in the cochlea of noise-exposed rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 5, pp. 594–599, 2020, [Online]. Available: https://sid.ir/paper/745441/en

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