Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHI LEILA; TANWIR FARZEEN; Yousefi Babadi Vahid

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:4 Page(s): 705-713

Download Full-Text

View:

139

Download:

Cites:

Information Journal Paper

Title

Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats

Author(s)

SADEGHI LEILA | TANWIR FARZEEN | Yousefi Babadi Vahid | Issue Writer Certificate

Keywords

Catecholamine

Cognitive disorder

Depression like behavior

Hippocampus

Manganism

Mitochondria dysfunction

Abstract

Purpose: Manganism is a Cognitive disorder take places in peoples are exposed to environmental manganese pollution. Overexposure to manganese ion (Mn2+) mainly influences central nervous system and causes symptoms that increase possibility of hippocampal damages. Methods: In this study rats were administrated by two different doses of MnCl2 and behavioral and physiological consequences were evaluated. We also investigated effects of E. Amoenum on Mn2+-imposed toxicity by behavioral, biochemical, immunoblotting and histological studies on Hippocampus tissue. Results: Results showed metal overexposure increases oxidative stress mainly by lipid peroxidation and reactive oxygen species overproduction. Histological studies and caspase 3 analyses by immunoblotting revealed Mn2+ induced apoptosis from mitochondrial-dependent pathway in the presence of low metal dose. This study provides evidence that oral administration of E. amoenum extract inhibited manganese neurotoxicity by oxidative stress attenuation and apoptosis reduction that lead to improved Depression like behavior. Plant extract also increased Catecholamine content in Mn2+ treated Hippocampus. Conclusion: As molecular and pathophysiological effects of E. amoenum, it could be considered as a pre-treatment for Parkinson and Parkinson like disorders in high-risk people.

Cites

Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus

References

No record.

Cite

APA: Copy

SADEGHI, LEILA, TANWIR, FARZEEN, & Yousefi Babadi, Vahid. (2018). Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats. ADVANCED PHARMACEUTICAL BULLETIN, 8(4), 705-713. SID. https://sid.ir/paper/745507/en

Vancouver: Copy

SADEGHI LEILA, TANWIR FARZEEN, Yousefi Babadi Vahid. Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(4):705-713. Available from: https://sid.ir/paper/745507/en

IEEE: Copy

LEILA SADEGHI, FARZEEN TANWIR, and Vahid Yousefi Babadi, “Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 4, pp. 705–713, 2018, [Online]. Available: https://sid.ir/paper/745507/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops