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Information Journal Paper

Title

Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia

Pages

  340-342

Abstract

 Background: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma with elevated serum immunoglobulin M and multi-organ involvement. Primary systemic amyloidosis usually develops due to immunoglobulin light chains depositions in different organs due to an underlying gammopathy. Case presentation: Our patient was an 86-year-old man with macroglossia, ecchymotic patches and bullous lesions associated with a skin laxity on the periorbital, palmar, and glans penis areas. Skin biopsy confirmed dermal amyloid depositions. In serum immunofixation electrophoresis, prominent monoclonal immunoglobulin-M lambda light chains were detected associated with prominent lymphoplasmacytic infiltration in bone marrow biopsy which was diagnosed as Waldenstrom macroglobulinemia. Conclusion: Skin involvement presenting as cutaneous amyloidosis could be the first manifestation of Waldenstrom macroglobulinemia. We should think about an underlying gammopathy in an old patient with skin laxity and ecchymosis.

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    • Cite

    APA: Copy

    Rafiei, Rana, EFTEKHARI, HOJAT, & RAFIEE, BEHNAM. (2020). Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia. CASPIAN JOURNAL OF INTERNAL MEDICINE, 11(3), 340-342. SID. https://sid.ir/paper/745713/en

    Vancouver: Copy

    Rafiei Rana, EFTEKHARI HOJAT, RAFIEE BEHNAM. Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2020;11(3):340-342. Available from: https://sid.ir/paper/745713/en

    IEEE: Copy

    Rana Rafiei, HOJAT EFTEKHARI, and BEHNAM RAFIEE, “Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 11, no. 3, pp. 340–342, 2020, [Online]. Available: https://sid.ir/paper/745713/en

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