Determination of Methyldopa and Paracetamol in Pharmaceutical Samples by a Low Cost Genipa americana L. Polyphenol Oxidase Based Biosensor

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Antunes Rafael Souza; Thomaz Douglas Vieira; Garcia Luane Ferreira; de Souza Gil Eric; Somerset Vernon Sydwill; Lopes Flavio Marques

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:3 Page(s): 416-422

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Title

Determination of Methyldopa and Paracetamol in Pharmaceutical Samples by a Low Cost Genipa americana L. Polyphenol Oxidase Based Biosensor

Author(s)

Keywords

Jenipapo (Genipa americana L.)

Biosensor

Methyldopa

Paracetamol

Abstract

Purpose: Jenipapo fruit (Genipa americana L) is a natural source of polyphenol oxidases (PPOs) whose potential in pharmaceutical analysis is noteworthy. Henceforth, this work reports the electrochemical study of a low-cost PPO-based Biosensor produced from the crude extract of Jenipapo fruits and accounts a practical approach to employ this Biosensor in the determination of Methyldopa and Paracetamol in pharmaceutical samples. Methods: In order to investigate the electrochemical properties of the Biosensor, theoretical and practical approaches were employed, and both samples and the Biosensor were analyzed through electrochemical impedance spectroscopy (EIS) and voltammetric techniques, namely: differential pulse voltammetry (DPV) and cyclic voltammetry (CV). Results: showcased that the Biosensor presented good analytical features, as well as low detection limits (8 μ mol L-1 for Methyldopa and 5 μ mol L-1 for Paracetamol). The relative standard deviation was less than 5% mid-assay. Conclusion: The use of this Biosensor is a reliable, low cost and useful alternative in the pharmaceutic determination of phenolic drugs (e. g. Methyldopa and Paracetamol).

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APA: Copy

Antunes, Rafael Souza, Thomaz, Douglas Vieira, Garcia, Luane Ferreira, de Souza Gil, Eric, Somerset, Vernon Sydwill, & Lopes, Flavio Marques. (2019). Determination of Methyldopa and Paracetamol in Pharmaceutical Samples by a Low Cost Genipa americana L. Polyphenol Oxidase Based Biosensor. ADVANCED PHARMACEUTICAL BULLETIN, 9(3), 416-422. SID. https://sid.ir/paper/745986/en

Vancouver: Copy

Antunes Rafael Souza, Thomaz Douglas Vieira, Garcia Luane Ferreira, de Souza Gil Eric, Somerset Vernon Sydwill, Lopes Flavio Marques. Determination of Methyldopa and Paracetamol in Pharmaceutical Samples by a Low Cost Genipa americana L. Polyphenol Oxidase Based Biosensor. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(3):416-422. Available from: https://sid.ir/paper/745986/en

IEEE: Copy

Rafael Souza Antunes, Douglas Vieira Thomaz, Luane Ferreira Garcia, Eric de Souza Gil, Vernon Sydwill Somerset, and Flavio Marques Lopes, “Determination of Methyldopa and Paracetamol in Pharmaceutical Samples by a Low Cost Genipa americana L. Polyphenol Oxidase Based Biosensor,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 3, pp. 416–422, 2019, [Online]. Available: https://sid.ir/paper/745986/en

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