10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest

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Rasmussen Andrea; Murphy Kaylee; Hoskin David W.

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:4 Page(s): 685-689

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Title

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest

Author(s)

Rasmussen Andrea | Murphy Kaylee | Hoskin David W. | Issue Writer Certificate

Keywords

Cell cycle

Proliferation

Ginger

10-Gingerol

Ovarian cancer

Abstract

Purpose: Gingerol homologs found in the rhizomes of Ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-Gingerol on Ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth. Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell Proliferation, cytotoxicity and Cell cycle progression, and western blotting was used to measure cyclin protein expression. Results: Ovarian cancer cells that were treated with 10-Gingerol experienced a time-and dose-dependent decrease in cell number, which was due to a reduction in cell Proliferation rather than a cytotoxic effect. Reduced Proliferation of 10-Gingerol-treated Ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the Cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-Gingerol. Conclusion: These findings revealed that 10-Gingerol caused a G2 arrest-associated suppression of Ovarian cancer cell growth, which may be exploited in the management of Ovarian cancer.

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APA: Copy

Rasmussen, Andrea, Murphy, Kaylee, & Hoskin, David W.. (2019). 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest. ADVANCED PHARMACEUTICAL BULLETIN, 9(4), 685-689. SID. https://sid.ir/paper/746010/en

Vancouver: Copy

Rasmussen Andrea, Murphy Kaylee, Hoskin David W.. 10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(4):685-689. Available from: https://sid.ir/paper/746010/en

IEEE: Copy

Andrea Rasmussen, Kaylee Murphy, and David W. Hoskin, “10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 4, pp. 685–689, 2019, [Online]. Available: https://sid.ir/paper/746010/en

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