Inactivation of β 1-adrenergic receptor in the basolateral amygdala nucleus attenuated anxiety-like behaviour in response to foot-shock stress in the male rat

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Hosseinmardi Leila; SHIRAVI ABDOLHOSSEIN; MEFTAHI GHOLAM HOSSEIN; AFARINESH MOHAMMAD REZA

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Journal: Physiology and Pharmacology Year:2019 | Volume:23 | Issue:2 Page(s): 101-114

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Title

Inactivation of β 1-adrenergic receptor in the basolateral amygdala nucleus attenuated anxiety-like behaviour in response to foot-shock stress in the male rat

Author(s)

Hosseinmardi Leila | SHIRAVI ABDOLHOSSEIN | MEFTAHI GHOLAM HOSSEIN | AFARINESH MOHAMMAD REZA | Issue Writer Certificate

Keywords

Anxiety-like behaviour

Basolateral amygdala

1-Adrenergic receptor

Stress

Abstract

Introduction: The Basolateral amygdala (BLA) is implicated in Stress-related disorders such as anxiety-like behavior. Substantial data exist demonstrating a close relationship between anxiety and adrenergic receptor function in patients with anxiety disorders; however, little is known about the effects of the β; 1 adrenergic receptor in the BLA on anxiety. This experiment examined the effects of the β; 1 adrenergic receptor in the BLA on anxiety-like behavior. Methods: Male Wistar rats were exposed to foot-shock Stress four consecutive days that were uncontrollable. The β; 1-adrenoreceptor agonist (dobutamine; 0. 5μ l/side) or antagonist (atenolol; 0. 25μ l/side) bilaterally infused into the BLA five minutes before foot-shock Stress. Anxiety-like behaviors were assessed 24h after four consecutive day’ s uncontrollable Stress using elevated plus-maze (EPM) and open field test (OFT). Results: Findings of EPM revealed that foot-shock Stress leads to anxiogenic effect with reduction the time spent and the number of entries into the open arms and increased head-dipping. Intra-BLA infusions of atenolol before Stress affected animal behavior differently, such that it significantly increased the time spent and the number of entries into the open arms and decreased head-dipping. Also, OFT results showed the intra-BLA infusion of atenolol increased the time periods spent in the center, number of center entries and reduced the number of rearing as compared with the Stress group. Conclusion: These results suggest that the anxiety-like behavior observed after the foot-shock Stress is mediated, in part, by exaggerated β; 1 adrenergic receptor acting at the BLA.

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APA: Copy

Hosseinmardi, Leila, SHIRAVI, ABDOLHOSSEIN, MEFTAHI, GHOLAM HOSSEIN, & AFARINESH, MOHAMMAD REZA. (2019). Inactivation of β 1-adrenergic receptor in the basolateral amygdala nucleus attenuated anxiety-like behaviour in response to foot-shock stress in the male rat. PHYSIOLOGY AND PHARMACOLOGY, 23(2), 101-114. SID. https://sid.ir/paper/746113/en

Vancouver: Copy

Hosseinmardi Leila, SHIRAVI ABDOLHOSSEIN, MEFTAHI GHOLAM HOSSEIN, AFARINESH MOHAMMAD REZA. Inactivation of β 1-adrenergic receptor in the basolateral amygdala nucleus attenuated anxiety-like behaviour in response to foot-shock stress in the male rat. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;23(2):101-114. Available from: https://sid.ir/paper/746113/en

IEEE: Copy

Leila Hosseinmardi, ABDOLHOSSEIN SHIRAVI, GHOLAM HOSSEIN MEFTAHI, and MOHAMMAD REZA AFARINESH, “Inactivation of β 1-adrenergic receptor in the basolateral amygdala nucleus attenuated anxiety-like behaviour in response to foot-shock stress in the male rat,” PHYSIOLOGY AND PHARMACOLOGY, vol. 23, no. 2, pp. 101–114, 2019, [Online]. Available: https://sid.ir/paper/746113/en

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