The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin

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Hallak Mohamad; Balci Hakan; Gunaydin Caner; Bilge S. Sirri

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Journal Paper

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Journal: Physiology and Pharmacology Year:2019 | Volume:23 | Issue:4 Page(s): 302-308

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Title

The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin

Author(s)

Hallak Mohamad | Balci Hakan | Gunaydin Caner | Bilge S. Sirri | Issue Writer Certificate

Keywords

Pregabalin

Somatic pain

Ketanserin

Atropine

Abstract

Introduction: Pregabalin (PGB) is an analog of gamma-aminobutyric acid (GABA) with antinociceptive, antihyperalgesic and antiallodynic properties which frequently used in clinical pain management. Effect of PBG in neuropathic pain, incisionalinflammatory injury, post-operational pain, chronic pain and experimental pain models have already shown. It has been already known that muscarinic and serotonergic-2A receptors have a role in pain transmission. Methods: in this study, role of muscarinic and serotonergic-2A receptors in antinociceptive effect of Pregabalin were evaluated with hot-plate and tail flick tests and effects of administered drugs on locomotor activity were measured with automated activity cage. Results: PGB treatment (30 and 100mg/kg) caused longer latency in hot plate and tail flick tests than saline group. That antinociceptive effect of Pregabalin abolished by Ketanserin (1mg/kg) and Atropine (1mg/kg) treatment. Conclusion: However, there is lack of knowledge about role of nociceptive pathways underlying Pregabalin mediated antinociception. Our results suggest that cholinergic and serotonergic systems have a role in antinociceptive effect of PGB which has seen in these Somatic pain tests.

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APA: Copy

Hallak, Mohamad, Balci, Hakan, Gunaydin, Caner, & Bilge, S. Sirri. (2019). The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin. PHYSIOLOGY AND PHARMACOLOGY, 23(4), 302-308. SID. https://sid.ir/paper/746121/en

Vancouver: Copy

Hallak Mohamad, Balci Hakan, Gunaydin Caner, Bilge S. Sirri. The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2019;23(4):302-308. Available from: https://sid.ir/paper/746121/en

IEEE: Copy

Mohamad Hallak, Hakan Balci, Caner Gunaydin, and S. Sirri Bilge, “The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin,” PHYSIOLOGY AND PHARMACOLOGY, vol. 23, no. 4, pp. 302–308, 2019, [Online]. Available: https://sid.ir/paper/746121/en

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