Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples (SHORT COMMUNICATION)

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Khanra Kalyani; Choudhuri Indranil; Bhattacharyya Nandan

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:5 Page(s): 355-359

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Information Journal Paper

Title

Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples (SHORT COMMUNICATION)

Author(s)

Khanra Kalyani | Choudhuri Indranil | Bhattacharyya Nandan | Issue Writer Certificate

Keywords

DNA polymerase β

Ovarian cancer

Single nucleotide polymorphism

Abstract

Background: DNA polymerase β (pol β ) is a key enzyme of base excision repair pathway. It is a 1-kb gene consisting of 14 exons. Its catalytic part lies between exon 8 and exon 14. Exon 12 has a role in deoxyribonucleotide triphosphate selection for nucleotide transferase activity. Methods: Genomic DNA was isolated from ovarian carcinoma samples. Single strand conformation polymorphism method was used to detect mutation in genomic DNA. Results: Twenty-four patients of the 152 pair of tumor samples (15. 8%) exhibited a point mutation (C→ G) in position 725 in exon 12, which shifts proline to arginine (P242R). Statistical analysis showed a significant (p < 0. 001) relationship between pol β mutation and the age of detection. Conclusion: This is a newly reported somatic mutation of pol β in ovarian carcinoma patients from India.

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APA: Copy

Khanra, Kalyani, Choudhuri, Indranil, & Bhattacharyya, Nandan. (2018). Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL, 22(5), 355-359. SID. https://sid.ir/paper/746575/en

Vancouver: Copy

Khanra Kalyani, Choudhuri Indranil, Bhattacharyya Nandan. Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples (SHORT COMMUNICATION). IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(5):355-359. Available from: https://sid.ir/paper/746575/en

IEEE: Copy

Kalyani Khanra, Indranil Choudhuri, and Nandan Bhattacharyya, “Detection of Somatic Mutation in Exon 12 of DNA Polymerase β in Ovarian Cancer Tissue Samples (SHORT COMMUNICATION),” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 5, pp. 355–359, 2018, [Online]. Available: https://sid.ir/paper/746575/en

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