Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis

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Ebad Mahmoud Ahmed; Fayed Notila; Fayed Laila; Alkanj Souad; Abdelkarim Ahmed; Farwati Haya; Hanafy Aya; NEGIDA AHMED; Ebada Mohamed; Noser Yousef

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2019 | Volume:18 | Issue:4 Page(s): 2144-2156

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Title

Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis

Author(s)

Keywords

Alpha-lipoic acid

Diabetes Mellitus

Thioctic Acid

Metabolic Diseases

Meta-analysis

Abstract

Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with Diabetes Mellitus (DM). We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data on glycated hemoglobin (HbA1c), blood glucose levels, lipid profile components, HOMA, and glutathione peroxidase (GPx) were extracted and pooled as the standardized mean difference (SMD) in a random effect model Meta-analysis using RevMan version 5. 3. Ten studies (n = 553 patients) were included. In the term of HBA1C, the overall SMD did not favor either of the two groups (SMD = 0. 01, 95% CI [-0. 32, 0. 35]; p = 0. 94) in uncomplicated T2DM patients. Moreover, there was no statistically significant difference between the two groups in terms of FBG (SMD =-0. 06, 95% CI [-0. 44, 0. 33]; p = 0. 78), PPBG (SMD = 0. 04, 95% CI [-0. 27, 0. 34]; p = 0. 82), HDL (SMD =-0. 05, 95% CI [-0. 35, 0. 25]; p = 0. 75), LDL (SMD =-0. 05, 95% CI [-0. 33, 0. 23]; p = 0. 75). In terms of GPx, ALA was superior to placebo (SMD = 0. 43, 95% CI [0. 07, 0. 8]; p = 0. 02). Our analysis showed that ALA was not superior to placebo in terms of HBA1C, LDL, HDL, TC, TG reduction in uncomplicated T2DM. However, in terms of GPx, ALA was significantly superior to the placebo. Further studies with larger sample sizes should investigate different doses of ALA in DM patients.

Cites

Effect of Alpha-Lipoic Acid on Blood Hormonal Parameters and Follicular Fluid Oxidative Stress Factors in Infertile Women with Polycystic Ovary Syndrome Undergoing Intracytoplasmic Sperm Injection

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APA: Copy

Ebad, Mahmoud Ahmed, Fayed, Notila, Fayed, Laila, Alkanj, Souad, Abdelkarim, Ahmed, Farwati, Haya, Hanafy, Aya, NEGIDA, AHMED, Ebada, Mohamed, & Noser, Yousef. (2019). Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(4), 2144-2156. SID. https://sid.ir/paper/746657/en

Vancouver: Copy

Ebad Mahmoud Ahmed, Fayed Notila, Fayed Laila, Alkanj Souad, Abdelkarim Ahmed, Farwati Haya, Hanafy Aya, NEGIDA AHMED, Ebada Mohamed, Noser Yousef. Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(4):2144-2156. Available from: https://sid.ir/paper/746657/en

IEEE: Copy

Mahmoud Ahmed Ebad, Notila Fayed, Laila Fayed, Souad Alkanj, Ahmed Abdelkarim, Haya Farwati, Aya Hanafy, AHMED NEGIDA, Mohamed Ebada, and Yousef Noser, “Efficacy of Alpha-lipoic Acid in The Management of Diabetes Mellitus: A Systematic Review and Meta-analysis,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 4, pp. 2144–2156, 2019, [Online]. Available: https://sid.ir/paper/746657/en

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