Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5

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Gudi Mihir A.; Yi Chung Y.; Nohadani Mahrokh

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Journal Paper

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Journal: Iranian Journal of Pathology Year:2019 | Volume:14 | Issue:2 Page(s): 113-121

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Title

Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5

Author(s)

Gudi Mihir A. | Yi Chung Y. | Nohadani Mahrokh | Issue Writer Certificate

Keywords

Immunohistochemistry

Disease of Breast

Monoclonal Antibody

Abstract

Background and Objective: Anti-CK5/6 monoclonal antibodies have an established role in breast disease diagnosis. Anti-CK5 monoclonal antibodies have recently become commercially available. There has been growing interest in the staining characteristics of anti-CK5 and its potential diagnostic role in place of anti-CK5/6. We aim to compare and contrast the staining characteristics of anti-CK5/6 vs anti-CK5. Material and Methods: 58 tissue blocks containing 122 different lesions were selected from tissue archives. Two specimens (groups) were taken from each lesion One (group) was stained with anti-CK5 and the other (group) with anti-CK5/6 monoclonal antibodies, using the Streptavidin-biotin immuno-peroxidase method. The two groups of slides were compared and contrasted for lesion staining pattern and for intensity, using light microscopy. Results: Results showed that the diagnostic staining pattern was exactly the same in both anti-CK5 and anti-CK5/6 groups, and also showed that anti-CK5, stained most of the lesions more intensely than anti-CK5/6. Conclusion: Anti-CK5 performed at least as well (for lesion-pattern staining), and better (for lesion staining intensity) than did anti-CK5/6 in the diagnosis of a wide range of breast tissues and lesions. It may be justified to safely replace anti-CK5/6 with anti-CK5 in future routine clinical use, with resultant diagnostic and economic benefits.

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APA: Copy

Gudi, Mihir A., Yi, Chung Y., & Nohadani, Mahrokh. (2019). Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(2), 113-121. SID. https://sid.ir/paper/747374/en

Vancouver: Copy

Gudi Mihir A., Yi Chung Y., Nohadani Mahrokh. Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(2):113-121. Available from: https://sid.ir/paper/747374/en

IEEE: Copy

Mihir A. Gudi, Chung Y. Yi, and Mahrokh Nohadani, “Comparing the Diagnostic Outcomes of Staining Various Breast Lesions with Either Anti-CK 5/6 or Anti-CK 5,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 2, pp. 113–121, 2019, [Online]. Available: https://sid.ir/paper/747374/en

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