Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection

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Kananizadeh Pegah; OHADIAN MOGHADAM SOLMAZ; SADEGHI YASAMAN; RAHIMI FOROUSHANI ABBAS; Adibi Hossein; POURMAND MOHAMMAD REZA

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2019 | Volume:14 | Issue:4 Page(s): 329-337

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Title

Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection

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Keywords

Diabetic foot infection

Methicillin-resistant Staphylococcus aureus

SCCmec typing

Abstract

Background & Objective: Diabetic foot ulcer (DFU), is one of the most frequent causes for hospitalizations in patients with diabetes. A major problem in the treatment of DFU is the increased-incidence of Methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to determine the SCCmec types of MRSA isolates and their epidemiology among patients with diabetes. Methods: This study was carried out on 145 diabetic patients with DFUs. The antibiotic susceptibility tests (ASTs) were performed using the disk diffusion method and E-test technique. SCCmec typing was done by multiplex PCR. Moreover, the presence of virulence toxin genes, including pvl and lukED was detected by PCR assay. Results: In 145 samples from which S. aureus was predominantly isolated, 19. 48% were MRSA. Analysis of MRSA isolates revealed that the most prevalent SCCmec type was type IV (46. 7%) followed by type III (30. 0%) and type V (20. 0%). One strain (3. 3%) was untypeable. The prevalence of pvl and lukED was 56. 7% and 100%, respectively. Conclusion: The high prevalence of MRSA in DFUs represents the high levels of antibiotic usage among patients with diabetes. In this study, resistance to other important clinical antibiotics was detected among MRSA isolates. The high proportion of SCCmec type IV and V strains, even in former hospitalized patients, indicates the entrance of these clones to the clinical setting.

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APA: Copy

Kananizadeh, Pegah, OHADIAN MOGHADAM, SOLMAZ, SADEGHI, YASAMAN, RAHIMI FOROUSHANI, ABBAS, Adibi, Hossein, & POURMAND, MOHAMMAD REZA. (2019). Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(4), 329-337. SID. https://sid.ir/paper/747417/en

Vancouver: Copy

Kananizadeh Pegah, OHADIAN MOGHADAM SOLMAZ, SADEGHI YASAMAN, RAHIMI FOROUSHANI ABBAS, Adibi Hossein, POURMAND MOHAMMAD REZA. Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(4):329-337. Available from: https://sid.ir/paper/747417/en

IEEE: Copy

Pegah Kananizadeh, SOLMAZ OHADIAN MOGHADAM, YASAMAN SADEGHI, ABBAS RAHIMI FOROUSHANI, Hossein Adibi, and MOHAMMAD REZA POURMAND, “Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Diabetic Foot Infection,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 4, pp. 329–337, 2019, [Online]. Available: https://sid.ir/paper/747417/en

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