مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

189
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

126
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’ s Diseases

Pages

  430-436

Abstract

 Purpose: Alzheimer’ s disease (AD) is a chronic neurodegeneRative disorder, with an increasing prevalence Rate, mostly related to cholinergic system. According to the difficulties and complications in management of AD, this study was carried out to evaluate the efficacy of Grape seed oil (GSO) on Scopolamine (Scop) induced Alzheimer’ s in male Rats. Methods: 64 healthy male Wistar Rats received different treatments such as: normal saline (NS), donepezil (Don), Scop and GSO, according to the previously designed protocol. Morris (MWM) was applied for Spatial memory tests. Right after the behavioral tests, the brains were removed and the hippocampus was sepaRated for evaluation of Acetylcholine levels as well as cell death and neuro inflammation. Results: The results of the test day indicated that the mean Q2 time was increased in both GSO test groups (P < 0. 05) and Don treated group (P < 0. 001). The spectrophotometric findings affirm that both GSO co-treatment and post-treatment were effective in augmenting brain Acetylcholine levels (P < 0. 01 and P < 0. 05 respectively). The microscopic findings of H&E dyed tissues confirmed the above mentioned results for different treatments except for GSO post treatment, in which the viability of cells were very low. Conclusion: The results implied that supplementation of Rats with GSO caused a significant augmentation in Spatial memory performance as well as Acetylcholine levels and cell viability in the presence of Scop. This effect was comparable to that of Don especially when GSO was used as co-treatment.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Berahmand, Farnoosh, Anoush, Golnoush, HOSSEINI, MIR JAMAL, & ANOUSH, MAHDIEH. (2020). Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’ s Diseases. ADVANCED PHARMACEUTICAL BULLETIN, 10(3), 430-436. SID. https://sid.ir/paper/748009/en

    Vancouver: Copy

    Berahmand Farnoosh, Anoush Golnoush, HOSSEINI MIR JAMAL, ANOUSH MAHDIEH. Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’ s Diseases. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2020;10(3):430-436. Available from: https://sid.ir/paper/748009/en

    IEEE: Copy

    Farnoosh Berahmand, Golnoush Anoush, MIR JAMAL HOSSEINI, and MAHDIEH ANOUSH, “Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer’ s Diseases,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 10, no. 3, pp. 430–436, 2020, [Online]. Available: https://sid.ir/paper/748009/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button