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Information Journal Paper

Title

Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome

Pages

  37-44

Abstract

 Objectives Cyclic vomiting syndrome (CVS) is a chronic functional gastrointestinal disorder with no certain treatment. We aimed to compare the efficacy of Amitriptyline and Topiramate on prophylactic therapy of CVS. Materials and Methods Thisrandomizedclinicaltrial(registrationnumber: IRCT2015102316844N2) was conducted during 2016 in Isfahan, central Iran. The inclusion criteria were CVS patients (based on Rome III) aging 3-15 yr with normal physical examination, no metabolic disorder, and no gastrointestinal obstruction or renal impairment. Recruited patients were divided into two groups of Amitriptyline (1 mg/kg/d) and Topiramate (1-2 mg/kg/d) and were followed for 3-months. The outcome was evaluated by comparing severity of attacks (monthly frequency and duration of attacks) before and after intervention. Results Thirty-six children entered each group and two patients left the Amitriptyline group. Patients and disease characteristics were similar between groups before intervention (P>0. 05). The frequency of attacks (standard deviation) after intervention in Amitriptyline and Topiramate group was 0. 91 (0. 40) and 1. 07 (0. 55), respectively (P=0. 368) and the duration of attacks (SD) after intervention were 3. 43 (2. 46) and 4. 90 (3. 03), respectively (P=0. 017). Twenty-three patients (68%) in Amitriptyline group and 14 patients (39%) in Topiramate group stopped having attacks after intervention (P=0. 016). Conclusion Amitriptyline is a better choice to reduce severity of CVS attacks compared to Topiramate, in a short-term evaluation. Studies with longer follow-up are required to investigate these findings in a longer period.

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    APA: Copy

    BAGHERIAN, Zahra, YAGHINI, OMID, SANEIAN, HOSEIN, & BADIHIAN, SHERVIN. (2019). Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 13(1), 37-44. SID. https://sid.ir/paper/748050/en

    Vancouver: Copy

    BAGHERIAN Zahra, YAGHINI OMID, SANEIAN HOSEIN, BADIHIAN SHERVIN. Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2019;13(1):37-44. Available from: https://sid.ir/paper/748050/en

    IEEE: Copy

    Zahra BAGHERIAN, OMID YAGHINI, HOSEIN SANEIAN, and SHERVIN BADIHIAN, “Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 13, no. 1, pp. 37–44, 2019, [Online]. Available: https://sid.ir/paper/748050/en

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