مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

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Information Journal Paper

Title

Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus

Pages

  368-376

Abstract

 Oxidative stress (OS) is a main mechanism in organophosphorus poisoning. The effects of Calcium channel blockers have been confirmed in decreasing of oxidative stress. In the current study, the effects of Amlodipine (AM), as a Calcium channel blocker, were evaluated on oxidative damages induced by Diazinon (DZN) in Hippocampus tissue of Wistar rats. Forty-two rats were divided into six groups and treated intraperitoneally for two weeks. Group 1 served as control received vehicle, group 2 was treated with 9 mg/kg of AM, group 3 (positive control) received DZN (32 mg/kg), Groups 4, 5, and 6 were treated with 3, 6, and 9 mg/kg of AM adjunct with DZN (32 mg/kg), respectively. After 14 days, all the animals were sacrificed under anesthesia and Hippocampus tissue and blood samples were collected for biochemical analysis and histopathology experiments. The results showed that DZN caused significant increase in lipid peroxidation (P < 0. 001), nitric oxide (P < 0. 001) and lactate dehydrogenase (P < 0. 001) levels, depletion of total antioxidant capacity (P < 0. 01), and structural changes in Hippocampus tissues. Following AM administration, a significant improvement was observed in oxidative biomarkers in Hippocampus tissues. Additionally, our biochemical findings were related well with histopathological examinations. In conclusion, the data of this study indicated that AM administration may prevent oxidative damages via improving of energy production and preventing of free radical formation in DZN-exposed animals.

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    APA: Copy

    NILI AHMADABADI, AMIR, Ali Heidar, Fahimeh, RANJBAR, AKRAM, MOUSAVI, LEILA, Ahmadimoghaddam, Davoud, LARKI HARCHEGANI, AMIR, & Ghafouri Khosrowshahi, Abolfazl. (2018). Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 13(4), 368-376. SID. https://sid.ir/paper/748097/en

    Vancouver: Copy

    NILI AHMADABADI AMIR, Ali Heidar Fahimeh, RANJBAR AKRAM, MOUSAVI LEILA, Ahmadimoghaddam Davoud, LARKI HARCHEGANI AMIR, Ghafouri Khosrowshahi Abolfazl. Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2018;13(4):368-376. Available from: https://sid.ir/paper/748097/en

    IEEE: Copy

    AMIR NILI AHMADABADI, Fahimeh Ali Heidar, AKRAM RANJBAR, LEILA MOUSAVI, Davoud Ahmadimoghaddam, AMIR LARKI HARCHEGANI, and Abolfazl Ghafouri Khosrowshahi, “Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 13, no. 4, pp. 368–376, 2018, [Online]. Available: https://sid.ir/paper/748097/en

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