مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

134
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

117
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Role of Allium saralicum Extract on Prevention of Acetaminophen-Induced Hepatic Failure: an Experimental Study

Pages

  43-51

Abstract

 Background and objectives: acetaminophen (APAP) is a common analgesic medicine whose overdose leads to severe hepatic dysfunction. Due to the known antioxidant properties of Allium species, the present study aimed to evaluate the protective effects of Allium saralicum plant on APAP induced liver toxicity. Methods: The hydro-alcoholic extract of A. saralicum was prepared by maceration and ultrasonic methods. Forty-two rats in seven groups were treated by gavage as follows: groups 1 and 2 received normal saline, groups 3 received 400 mg/kg of A. saralicum hydro-alcoholic extract, and the groups 4-7 were treated with 50, 100, 200 and 400 mg/kg of A. saralicum extract, respectively. After two consecutive weeks, the therapeutic groups, as well as the positive control (APAP) group, were administered a single dose of APAP (2 g/kg). After 48 hours, the animals were anesthetized, and blood and liver samples were collected for histological and biochemical examinations. Results: Our findings indicated that APAP caused a significant rise in ALT (p<0. 001), AST (p<0. 001), ALP (p<0. 001) and LDH (p<0. 001) serum levels, total and direct bilirubin (p<0. 001), hepatic lipid peroxidation (LPO; p<0. 001) and nitric oxide (NO; p<0. 001). In addition, APAP let to the decreasing of the total antioxidant capacity (TAC; p< 0. 001), total thiol molecules (TTM; p<0. 001), and structural changes in the hepatic tissue. Following administration of A. saralicum extract, a remarkable improvement was observed in the functional and oxidative stress indices of liver tissue alongside histopathologic alterations. Conclusion: Our results showed that A. saralicum extract significantly improved APAP-induced hepatic failure through inhibition of oxidative/nitrosative stress.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Alvandi, Mahdi, Dastan, Dara, SOLEIMANI ASL, SARA, & NILI AHMADABADI, AMIR. (2020). The Role of Allium saralicum Extract on Prevention of Acetaminophen-Induced Hepatic Failure: an Experimental Study. RESEARCH JOURNAL OF PHARMACOGNOSY, 7(2), 43-51. SID. https://sid.ir/paper/759476/en

    Vancouver: Copy

    Alvandi Mahdi, Dastan Dara, SOLEIMANI ASL SARA, NILI AHMADABADI AMIR. The Role of Allium saralicum Extract on Prevention of Acetaminophen-Induced Hepatic Failure: an Experimental Study. RESEARCH JOURNAL OF PHARMACOGNOSY[Internet]. 2020;7(2):43-51. Available from: https://sid.ir/paper/759476/en

    IEEE: Copy

    Mahdi Alvandi, Dara Dastan, SARA SOLEIMANI ASL, and AMIR NILI AHMADABADI, “The Role of Allium saralicum Extract on Prevention of Acetaminophen-Induced Hepatic Failure: an Experimental Study,” RESEARCH JOURNAL OF PHARMACOGNOSY, vol. 7, no. 2, pp. 43–51, 2020, [Online]. Available: https://sid.ir/paper/759476/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button