Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations

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BORZOUEISILEH SAJAD; SHABESTANI MONFARED ALI; Ghorbani Hossein; MORTAZAVI S.M.J.; ZABIHI EBRAHIM; POURAMIR MEHDI; Doustimotlagh Amir Hossein; SHAFIEE MOHSEN; Niksirat Fatemeh

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Journal: Caspian Journal of Internal Medicine Year:2020 | Volume:11 | Issue:3 Page(s): 315-323

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Title

Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations

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Keywords

EMF

Ionizing radiation

Liver

liver function tests

Oxidative stress

Abstract

Background: Compared to past decades, humans are exposed to rapidly increasing levels of radiofrequency electromagnetic radiations (RF-EMF). Despite numerous studies, the biological effects of human exposure to different levels of RF-EMF are not fully understood yet. This study aimed to evaluate the bioeffects of exposure to "900/1800 MHz" and “ 2. 4 GHz" RF-EMFs, and x-rays alone as well as their potential interactions, i. e. inducing simple additive, adaptive, or synergistic effects. Methods: 120 Wistar rats were randomly divided into ten groups of 12 each. The rats were exposed to RF-EMF, 10 cGy, and 8 Gy x-rays, a combination of these exposures, or only sham-exposed. The levels of Liver enzymes were determined in serum samples by an auto-analyzer. Moreover, the histopathological changes, and the levels of malondialdehyde (MDA), nitric oxide, ferric reducing antioxidant power, total thiols, and protein carbonyl (PCO) were measured. Results: Among the markers of Liver function, gamma-glutamyltransferase was not associated with irradiation but, aspartate transaminase, alanine transaminase, and alkaline phosphatase showed some levels of association. MDA and PCO levels after 8 Gy irradiation increased, but pre-exposure to RF-EMF could modulate their changes. At the cellular level, the frequency of lobular inflammation was associated with the type of intervention. Conclusion: The exposure to both ionizing and non-Ionizing radiations could alter some Liver function tests. A short term pre-exposure to RF-EMF before exposure to an 8 Gy challenging dose of x-rays caused the alterations in Oxidative stress markers and Liver function tests, which indicate that Oxidative stress is possibly involved in the adaptive response.

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APA: Copy

BORZOUEISILEH, SAJAD, SHABESTANI MONFARED, ALI, Ghorbani, Hossein, MORTAZAVI, S.M.J., ZABIHI, EBRAHIM, POURAMIR, MEHDI, Doustimotlagh, Amir Hossein, SHAFIEE, MOHSEN, & Niksirat, Fatemeh. (2020). Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations. CASPIAN JOURNAL OF INTERNAL MEDICINE, 11(3), 315-323. SID. https://sid.ir/paper/748113/en

Vancouver: Copy

BORZOUEISILEH SAJAD, SHABESTANI MONFARED ALI, Ghorbani Hossein, MORTAZAVI S.M.J., ZABIHI EBRAHIM, POURAMIR MEHDI, Doustimotlagh Amir Hossein, SHAFIEE MOHSEN, Niksirat Fatemeh. Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2020;11(3):315-323. Available from: https://sid.ir/paper/748113/en

IEEE: Copy

SAJAD BORZOUEISILEH, ALI SHABESTANI MONFARED, Hossein Ghorbani, S.M.J. MORTAZAVI, EBRAHIM ZABIHI, MEHDI POURAMIR, Amir Hossein Doustimotlagh, MOHSEN SHAFIEE, and Fatemeh Niksirat, “Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 11, no. 3, pp. 315–323, 2020, [Online]. Available: https://sid.ir/paper/748113/en

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