Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents

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FAGHIH ZEINAB; Rahmannejadi Nasrin; Sabet Razieh; ZOMORODIAN KAMIAR; Asad Mohammad; KHABNADIDEH SOGHRA

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Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2019 | Volume:14 | Issue:2 Page(s): 115-121

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Title

Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents

Author(s)

Keywords

Anticancer

Cytotoxicity

MTT

Quinazolinone

Abstract

Recently the quinazoline derivatives have attracted much attention for their Anticancer properties. In this study a series of new brominated quinazoline derivatives (1a-1g) were synthesized in two steps. In the first step we used N-bromosuccinimide to brominate the anthranilamid. Then in the second step we closed the quinazoline ring by different aromatic aldehydes. Our aldehydes contain different electron donating or electron withdrawing groups at different positions of the aromatic ring. The chemical structures of products were confirmed by spectroscopic methods such as IR, 1HNMR, 13CNMR, and mass spectroscopy. The cytotoxic activities of the compounds were assessed on three cancerous cell lines including MCF-7, A549, and SKOV3 using colorimetric MTT cytotoxic assay in comparison with cisplatin as a standard drug. Our results collectively indicated that 1f and 1g, exhibited the best anti-proliferative activities on three investigated cancerous cell lines.

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APA: Copy

FAGHIH, ZEINAB, Rahmannejadi, Nasrin, Sabet, Razieh, ZOMORODIAN, KAMIAR, Asad, Mohammad, & KHABNADIDEH, SOGHRA. (2019). Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 14(2), 115-121. SID. https://sid.ir/paper/748114/en

Vancouver: Copy

FAGHIH ZEINAB, Rahmannejadi Nasrin, Sabet Razieh, ZOMORODIAN KAMIAR, Asad Mohammad, KHABNADIDEH SOGHRA. Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2019;14(2):115-121. Available from: https://sid.ir/paper/748114/en

IEEE: Copy

ZEINAB FAGHIH, Nasrin Rahmannejadi, Razieh Sabet, KAMIAR ZOMORODIAN, Mohammad Asad, and SOGHRA KHABNADIDEH, “Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 14, no. 2, pp. 115–121, 2019, [Online]. Available: https://sid.ir/paper/748114/en

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