Antibiotic Resistance Among Helicobacter pylori Strains Isolated from Patients with Histopathological Changes of the Gastric Tissue Towards Metronidazole, Clarithromycin, and Ciproﬂ oxacin

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Bayati Saeed; AMIRMOZAFARI NOUR; ALEBOUYEH MASOUD; FARZI NASTARAN; EBRAHIMI DARYANI NASSER; ZALI MOHAMMAD REZA

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Journal: Archives of Clinical Infectious Diseases Year:2019 | Volume:14 | Issue:1 Page(s): 0-0

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Title

Antibiotic Resistance Among Helicobacter pylori Strains Isolated from Patients with Histopathological Changes of the Gastric Tissue Towards Metronidazole, Clarithromycin, and Ciproﬂ oxacin

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Keywords

Helicobacter pylori

Antimicrobial Resistance

Histopathological Changes

Minimum Inhibitory Concentration

Abstract

Background: The extent of antibiotic resistance among Helicobacter pylori strains inﬂ uences current clinical therapeutic regimens in each region. Objectives: This cross-sectional study aimed to determine the resistance property and Minimum Inhibitory Concentration (MIC50-90) of Helicobacter pylori strains toward metronidazole, clarithromycin, and ciproﬂ oxacin in patients with distinct gastric Histopathological Changes in Tehran, Iran. Methods: This study was conducted on 170 patients suﬀ ering from gastric complications in three hospitals in Tehran from October 2014 until March 2015. Two separate biopsy samples were collected from each patient and used for pathological and microbiological examinations. Antimicrobial susceptibility tests were performed by agar dilution method according to the CLSI guidelines. The MIC values and susceptibility to varying concentrations of metronidazole (4 to 64 g/mL), ciproﬂ oxacin (0. 5 to 16 g/mL), and clarithromycin (0. 25 to 16 g/mL) were determined based on EUCAST recommendations. Results: Our results indicated the infection with H. pylori in a frequency of 32% (55/170) among the study patients (female, 51% and male, 49%). Endoscopic ﬁ ndings indicated that 42% of the patients suﬀ ered from peptic ulcers, 33% from duodenal ulcers, and 25% with a non-ulcer disease. Pathological ﬁ ndings indicated 58% of the patients had chronic gastritis, 33% had active chronic gastritis, and 9% suﬀ ered from intestinal metaplasia. In terms of antibiotic susceptibility, nearly 76. 3%, 49%, and 45. 5% of the strains were resistant to metronidazole, clarithromycin, and ciproﬂ oxacin, respectively. The MIC values at which the growth of 50% and 90% of the strains was inhibited (MIC50-90) were 32-64 g/mL for metronidazole, 0. 5-16 g/mL for clarithromycin, and 2-16 g/mL for ciproﬂ oxacin. Conclusions: The overall resistance levels were relatively high among the study patients. Accordingly, the administration of other anti-Helicobacter drugs, as well as more appropriate therapeutic regimens based on laboratory results, is recommended in patients with a history of treatment failure.

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APA: Copy

Bayati, Saeed, AMIRMOZAFARI, NOUR, FARZI, NASTARAN, EBRAHIMI DARYANI, NASSER, & ZALI, MOHAMMAD REZA. (2019). Antibiotic Resistance Among Helicobacter pylori Strains Isolated from Patients with Histopathological Changes of the Gastric Tissue Towards Metronidazole, Clarithromycin, and Ciproﬂ oxacin. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 14(1), 0-0. SID. https://sid.ir/paper/748146/en

Vancouver: Copy

Bayati Saeed, AMIRMOZAFARI NOUR, FARZI NASTARAN, EBRAHIMI DARYANI NASSER, ZALI MOHAMMAD REZA. Antibiotic Resistance Among Helicobacter pylori Strains Isolated from Patients with Histopathological Changes of the Gastric Tissue Towards Metronidazole, Clarithromycin, and Ciproﬂ oxacin. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2019;14(1):0-0. Available from: https://sid.ir/paper/748146/en

IEEE: Copy

Saeed Bayati, NOUR AMIRMOZAFARI, NASTARAN FARZI, NASSER EBRAHIMI DARYANI, and MOHAMMAD REZA ZALI, “Antibiotic Resistance Among Helicobacter pylori Strains Isolated from Patients with Histopathological Changes of the Gastric Tissue Towards Metronidazole, Clarithromycin, and Ciproﬂ oxacin,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 14, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/748146/en

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