Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings

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Farajdokht Fereshteh; FARHOUDI MEHDI; Majdi Alireza; Zamanlu Masumeh; SADIGH ETEGHAD SAEED; Vahedi Shabnam; MAHMOUDI JAVAD

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 48-55

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Title

Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings

Author(s)

Keywords

Male sex

Testosterone

Stroke

Oxidative stress

Apoptosis

Abstract

Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. Here we reviewed current understanding of Testosterone (TES) neuroprotective activity against ischemic Stroke and mechanisms underlying these effects in aging. TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death. Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men.

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APA: Copy

Farajdokht, Fereshteh, FARHOUDI, MEHDI, Majdi, Alireza, Zamanlu, Masumeh, SADIGH ETEGHAD, SAEED, Vahedi, Shabnam, & MAHMOUDI, JAVAD. (2019). Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 48-55. SID. https://sid.ir/paper/748257/en

Vancouver: Copy

Farajdokht Fereshteh, FARHOUDI MEHDI, Majdi Alireza, Zamanlu Masumeh, SADIGH ETEGHAD SAEED, Vahedi Shabnam, MAHMOUDI JAVAD. Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):48-55. Available from: https://sid.ir/paper/748257/en

IEEE: Copy

Fereshteh Farajdokht, MEHDI FARHOUDI, Alireza Majdi, Masumeh Zamanlu, SAEED SADIGH ETEGHAD, Shabnam Vahedi, and JAVAD MAHMOUDI, “Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 48–55, 2019, [Online]. Available: https://sid.ir/paper/748257/en

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