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Information Journal Paper

Title

The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol (SHORT COMMUNICATION)

Pages

  291-294

Abstract

 The severe acute respiratory syndrome caused by COVID-19 is now a global catastrophic event. Currently there is no approved drug or vaccine for the disease. Methylene blue (MB, oxidized form, blue color) has been used in many different areas of clinical medicine, ranging from malaria to orthopedics. Methylene blue/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">LeucoMethylene blue (reduced form of MB, colorless) may be applied for the treatment of COVID-19 according to the scientific evidences. In severe patients, there is a cytokine storm (hyperinflammation) and high oxidative stress (OS). Inflammation and OS has a mutual correlation and exacerbate each other. In human body, MB first induces OS through absorbing electron (like a free radical) from other molecules, if the body could counteract to this OS, then reduced MB decreases OS through other mechanisms. Reduced MB could prevent inflammation, propagation of the virus RNA, and also improves hypoxia through reducing methemoglobin. Therefore, to avoid the increment of OS, we suggest using Methylene blue/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">LeucoMethylene blue through the following protocol: The IV cocktail contains 50 mg MB (1mg/kg, 50-kg weight), 1000-2000 mg vitamin C, 500-1000 mg N-Acetylcysteine (or glutathione or cysteine or α-lipoic acid) and 10-20 gr urea (optional) in 100 ml dextrose 5%. Before the injection, the cocktail should be kept in a dark place for 1-2 hour to become fade or colorless.

Cites

References

Cite

APA: Copy

HAMIDI ALAMDARI, DARYOUSH, Bagheri Moghaddam, Ahmad, AMINI, SHAHRAM, Hamidi Alamdari, Aida, Damsaz, Mohammad Amin, & Yar Ahmadi, Amir. (2020). The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol (SHORT COMMUNICATION). THE ARCHIVES OF BONE AND JOINT SURGERY, 8(Supplement 1), 291-294. SID. https://sid.ir/paper/748266/en

Vancouver: Copy

HAMIDI ALAMDARI DARYOUSH, Bagheri Moghaddam Ahmad, AMINI SHAHRAM, Hamidi Alamdari Aida, Damsaz Mohammad Amin, Yar Ahmadi Amir. The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol (SHORT COMMUNICATION). THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2020;8(Supplement 1):291-294. Available from: https://sid.ir/paper/748266/en

IEEE: Copy

DARYOUSH HAMIDI ALAMDARI, Ahmad Bagheri Moghaddam, SHAHRAM AMINI, Aida Hamidi Alamdari, Mohammad Amin Damsaz, and Amir Yar Ahmadi, “The Application of a Reduced Dye Used in Orthopedics as a Novel Treatment against Coronavirus (COVID-19): A Suggested Therapeutic Protocol (SHORT COMMUNICATION),” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 8, no. Supplement 1, pp. 291–294, 2020, [Online]. Available: https://sid.ir/paper/748266/en

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