Sofosbuvir and Ribavirin Combination Therapy Response in Various Hepatitis C Virus Genotypes in Peshawar, Khyber Pakhtunkhwa

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Haider Saima Ali; AHMAD BASHIR; ALI SAJID; Haider Ali; Bashir Shumaila; Mahmood Nourin

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Journal: Jundishapur Journal of Microbiology Year:2020 | Volume:13 | Issue:6 Page(s): 0-0

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Title

Sofosbuvir and Ribavirin Combination Therapy Response in Various Hepatitis C Virus Genotypes in Peshawar, Khyber Pakhtunkhwa

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Keywords

Hepatitis C Virus

Interferon

Direct-Acting Antiviral Drugs

Polymerase Chain Reaction

Khyber Pakhtunkhwa

Abstract

Background: Approximately 3% of the population worldwide is infected with Hepatitis C Virus (HCV). Different regimens have been used to treat HCV, each of which has its side effects and efficacy. Sofosbuvir, a direct-acting antiviral drug, has replaced all previous regimens with the highest response rate. However, its response is not fully covered in Pakistan, especially Khyber Pakhtunkhwa. Objectives: The study aimed to examine the response to Sofosbuvir and Ribavirin combination therapy in chronic HCV patients infected with various HCV genotypes. Methods: This study was conducted in Tertiary Care Hospitals, Peshawar, Pakistan. The patients were enrolled from January 2016 to March 2017. A total of 80 patients (57 naï ve and 23 non-responder) were enrolled in this study. The age range was 16-70 years, and the mean age was 36 2 years. Genotyping, biochemical profile, PCR tests, and liver ultrasounds were done for all of the enrolled subjects at the start and end of therapy. All patients were given Direct-Acting Antiviral Drugs for six months and then, the end of treatment response was noted. Results: A total of 80 subjects with HCV infection took part in the study, including 57 (71. 25%) treatment-naï ve and 23 (28. 75%) treatment non-responding patients. The end of therapy response was reported after 24 weeks of treatment. Among the 80 patients, 72 (90%) patients achieved the end of therapy response. The highest end of therapy response (100%) was noted in genotype 1 and mixed genotypes and patients with normal liver ultrasound. The lowest end of therapy response (70%) was found in un-type genotype and patients with an abnormal texture of liver ultrasound. The end of therapy response rate was higher in females than in males. Conclusions: In the current study, the minimal response was found in un-type genotypes and genotypes that did not respond to INF, as compared to treatment-naï ve subjects. Further research is needed to understand the relevant host and viral factors, with particular attention to relapsed patients and non-responders that are difficult to treat in the Pakistani population.

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APA: Copy

Haider, Saima Ali, AHMAD, BASHIR, ALI, SAJID, Haider, Ali, Bashir, Shumaila, & Mahmood, Nourin. (2020). Sofosbuvir and Ribavirin Combination Therapy Response in Various Hepatitis C Virus Genotypes in Peshawar, Khyber Pakhtunkhwa. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 13(6), 0-0. SID. https://sid.ir/paper/748385/en

Vancouver: Copy

Haider Saima Ali, AHMAD BASHIR, ALI SAJID, Haider Ali, Bashir Shumaila, Mahmood Nourin. Sofosbuvir and Ribavirin Combination Therapy Response in Various Hepatitis C Virus Genotypes in Peshawar, Khyber Pakhtunkhwa. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2020;13(6):0-0. Available from: https://sid.ir/paper/748385/en

IEEE: Copy

Saima Ali Haider, BASHIR AHMAD, SAJID ALI, Ali Haider, Shumaila Bashir, and Nourin Mahmood, “Sofosbuvir and Ribavirin Combination Therapy Response in Various Hepatitis C Virus Genotypes in Peshawar, Khyber Pakhtunkhwa,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 13, no. 6, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/748385/en

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