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Information Journal Paper

Title

Malignancy Rates in Thyroid Nodules Classified as Bethesda Categories III and IV: Retrospective Data from a Tertiary Center

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  0-0

Abstract

 Background: Thyroid fine needle aspiration (FNA) has a well-established role in the diagnosis of Thyroid Nodules, and the “ Bethesda system for reporting thyroid cytopathology” is used to interpret FNA results. Bethesda categories III and IV encompass varying risks of malignancy. In addition, there issomedebate in the literature abouthowto selectamongmanyacceptable treatment approaches. Objectives: To establish an association between these 2 cytological categories and malignancy rates in patients treated in a referral tertiary cancer center, where surgical treatment is recommended for all these patients. Methods: A total of 615 Thyroid Nodules (582 patients) were included in this retrospective study. There were 478 nodules that were classified as Bethesda category III and 137 nodules as Bethesda category IV. Electronic records were reviewed to establish a correlation between the FNA cytological results and the final histopathological analyses. Incidentally detected carcinomas were considered separately. Results: Among the bethesda category III group, 75 malignant nodules (15. 7%) were coincident with the target nodule (74 patients, 16. 2%). Incidental carcinomas were found in 13. 8% of these patients. The remaining 403 (84. 3%) target nodules were benign. Among the bethesda category IV nodules, 23 malignant nodules (16. 8%) were coincident with the target nodule. Incidental carcinomas were found in 25 patients (19. 7%). The other 114 target nodules were benign. A total of 46 patients (52. 3%) had carcinomas in the thyroid lobe contralateral to the one containing the target nodule, and 40 patients (45. 5%) had carcinomas exclusively in the contralateral lobe. Conclusions: We observed a 16% rate of malignancy in nodules classified as bethesda category III and 17% among bethesda category IV. When incidental carcinomas were included, the rates of malignancy doubled.

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    APA: Copy

    Cavalheiro, Beatriz Godoi, Nogueira Leite, Ana Kober, de Matos, Leandro Luongo, Miazaki, Aline Palermo, Ientile, Jan Marcel, V. Kulcsar, Marco Aurelio, & Cernea, Claudio Roberto. (2018). Malignancy Rates in Thyroid Nodules Classified as Bethesda Categories III and IV: Retrospective Data from a Tertiary Center. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(1), 0-0. SID. https://sid.ir/paper/748441/en

    Vancouver: Copy

    Cavalheiro Beatriz Godoi, Nogueira Leite Ana Kober, de Matos Leandro Luongo, Miazaki Aline Palermo, Ientile Jan Marcel, V. Kulcsar Marco Aurelio, Cernea Claudio Roberto. Malignancy Rates in Thyroid Nodules Classified as Bethesda Categories III and IV: Retrospective Data from a Tertiary Center. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;16(1):0-0. Available from: https://sid.ir/paper/748441/en

    IEEE: Copy

    Beatriz Godoi Cavalheiro, Ana Kober Nogueira Leite, Leandro Luongo de Matos, Aline Palermo Miazaki, Jan Marcel Ientile, Marco Aurelio V. Kulcsar, and Claudio Roberto Cernea, “Malignancy Rates in Thyroid Nodules Classified as Bethesda Categories III and IV: Retrospective Data from a Tertiary Center,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/748441/en

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