IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients

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MOHAMMADI SAEED; SEDIGHI SIMA; MEMARIAN ALI

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2019 | Volume:14 | Issue:3 Page(s): 236-242

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Title

IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients

Author(s)

MOHAMMADI SAEED | SEDIGHI SIMA | MEMARIAN ALI | Issue Writer Certificate

Keywords

Systemic lupus erythematosus

IL-17

glucocorticoids

pathogenesis

organ damage

treatment

Abstract

Background & Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic inflammatory immune response. Current therapies mostly rely on glucocorticoids which are accompanied by side-effects and mostly fail to achieve a favorable remission. Th17 subpopulation of T cells is increased in exacerbated SLE as IL-17 cytokine is overexpressed. However, IL-17 is reported to be resistant to glucocorticoids in various disorders. Here, we evaluated the plasma level of IL-17 among newly diagnosed and under-treatment SLE patients to understand the effect of glucocorticoids on Th17 response. Methods: A total of 40 female SLE patients and 20 age-and sex-matched normal subjects were enrolled. IL-17 plasma level was evaluated using ELISA cytokine assay and analyzed with previously obtained IL-10, IFN-γ , and GILZ levels. Results: Our findings revealed that IL-17 was overexpressed among under-treatment SLE patients. There was a significant correlation between IL-17 and IFN-γ and significant reverse correlations between IL-17, IL-10, and GILZ levels. IL-17 was not significantly correlated with the disease activity. Conclusion: According to the role of IL-17 in tissue injury and the fact that glucocorticoids are not successful in preventing organ damages in SLE, the overexpressed IL-17 in response to therapies could be introduced as an underlying reason.

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APA: Copy

MOHAMMADI, SAEED, SEDIGHI, SIMA, & MEMARIAN, ALI. (2019). IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients. IRANIAN JOURNAL OF PATHOLOGY (IJP), 14(3), 236-242. SID. https://sid.ir/paper/748448/en

Vancouver: Copy

MOHAMMADI SAEED, SEDIGHI SIMA, MEMARIAN ALI. IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2019;14(3):236-242. Available from: https://sid.ir/paper/748448/en

IEEE: Copy

SAEED MOHAMMADI, SIMA SEDIGHI, and ALI MEMARIAN, “IL-17 is Aberrantly Overexpressed Among Under-treatment Systemic Lupus Erythematosus Patients,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 14, no. 3, pp. 236–242, 2019, [Online]. Available: https://sid.ir/paper/748448/en

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